دورية أكاديمية
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Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson's disorder.

التفاصيل البيبلوغرافية
العنوان: Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson's disorder.
المؤلفون: Zhao H; Weifang Medical University, China.; Shandong Hongjitang Pharmaceutical Group Co. Ltd, China., Zhang Q; Engineer, Teaching Quality Monitoring and Evaluation Center, Guangdong Construction Polytechnic, China., Chen H; School of Pharmacy, Guangdong Lingnan Institue of Technology, China., Rahman MR; Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh., Faruquee HM; Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh.; Molecular Medicine, Translational Health Group, International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
المصدر: Saudi journal of biological sciences [Saudi J Biol Sci] 2021 Dec; Vol. 28 (12), pp. 6939-6945. Date of Electronic Publication: 2021 Aug 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Biological Society Country of Publication: Saudi Arabia NLM ID: 101543796 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-562X (Print) Linking ISSN: 22137106 NLM ISO Abbreviation: Saudi J Biol Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Riyadh : Saudi Biological Society : King Saud University, [2009]-
مستخلص: The novel coronavirus named SARS-CoV-2 has emerged at the end of 2019, which causes coronavirus disease (COVID-2019). Recent case reports of COVID-19 patients have revealed the onset of Parkinson's disease (PD) symptoms in patients who do not have a family history of the PD. However, till recently, no genetic impact or mechanisms that may induce Parkinsonism in COVID-19 patients or after COVID-19 have been found.. This study aimed to detect the commonly dysregulated genes, transcriptional regulators, and pathways between PD and COVID-19. We integrated genome-wide transcriptomic datasets from peripheral blood mononuclear cells (PBMC) samples from COVID-19 and PD and associated pathways. Our study revealed 81 upregulated and 48 downregulated differentially expressed genes (DEGs) shared between PD and COVID-19. These dysregulated genes were involved in key pathways "mitochondrion structure organization", "cell activation in immune response", and "signalling by interleukins". Our analysis showed RELA, TP53 and SP1 TFs that may regulate the upregulated DEGs. We have discovered key dysregulated genes and characterized the biological processes of commonly dysregulated in COVID-19 and PD, which could be used for the design of personalized treatment of PD following COVID-19.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2021 Published by Elsevier B.V. on behalf of King Saud University.)
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فهرسة مساهمة: Keywords: Blood gene expression; COVID-19; Molecular pathways; Parkinson’s disorder; Transcriptional signatures
تواريخ الأحداث: Date Created: 20210809 Latest Revision: 20231108
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8327558
DOI: 10.1016/j.sjbs.2021.07.074
PMID: 34366686
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-562X
DOI:10.1016/j.sjbs.2021.07.074