دورية أكاديمية
أعرض في EDS

Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients.

التفاصيل البيبلوغرافية
العنوان: Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients.
المؤلفون: Nshizirungu JP; Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco., Bennis S; Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco., Mellouki I; Department of Gastroenterology, Faculty of Medicine and Pharmacy, Abdelmalek Essaadi University, Tangier, Morocco., Sekal M; Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco., Benajah DA; Department of Gastroenterology, Hassan II University Hospital, Fez, Morocco., Lahmidani N; Department of Gastroenterology, Hassan II University Hospital, Fez, Morocco., El Bouhaddouti H; Department of Visceral Surgery, Hassan II University Hospital, Fez, Morocco., Ibn Majdoub K; Department of Visceral Surgery, Hassan II University Hospital, Fez, Morocco., Ibrahimi SA; Department of Gastroenterology, Hassan II University Hospital, Fez, Morocco., Celeiro SP; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Viana-Pereira M; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Munari FF; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Ribeiro GG; Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Duval V; Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Santana I; Pathology Department, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Reis RM; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
المصدر: Disease markers [Dis Markers] 2021 Jul 28; Vol. 2021, pp. 9980410. Date of Electronic Publication: 2021 Jul 28 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: eCollection Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : New York, NY : Hindawi Pub. Corp.
Original Publication: Chichester ; New York : Wiley, c1983-
مواضيع طبية MeSH: Biomarkers, Tumor/*genetics , Biomarkers, Tumor/*metabolism , Epstein-Barr Virus Infections/*diagnosis , Herpesvirus 4, Human/*isolation & purification , Stomach Neoplasms/*diagnosis, Adult ; Age Factors ; Aged ; Aged, 80 and over ; Databases, Genetic ; Diagnostic Tests, Routine ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/metabolism ; Female ; Herpesvirus 4, Human/genetics ; Humans ; Male ; Middle Aged ; Morocco ; Prognosis ; Sex Characteristics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/virology ; Survival Analysis
مستخلص: Introduction: The Cancer Genome Atlas (TCGA) project and Asian Cancer Research Group (ACRG) recently categorized gastric cancer into molecular subtypes. Nevertheless, these classification systems require high cost and sophisticated molecular technologies, preventing their widespread use in the clinic. This study is aimed to generating molecular subtypes of gastric cancer using techniques available in routine diagnostic practice in a series of Moroccan gastric cancer patients. In addition, we assessed the associations between molecular subtypes, clinicopathological features, and prognosis.
Methods: Ninety-seven gastric cancer cases were classified according to TCGA, ACRG, and integrated classifications using a panel of four molecular markers (EBV, MSI, E-cadherin, and p53). HER2 status and PD-L1 expression were also evaluated. These markers were analyzed using immunohistochemistry (E-cadherin, p53, HER2, and PD-L1), in situ hybridization (EBV and HER2 equivocal cases), and multiplex PCR (MSI).
Results: Our results showed that the subtypes presented distinct clinicopathological features and prognosis. EBV-positive gastric cancers were found exclusively in male patients. The GS (TCGA classification), MSS/EMT (ACRG classification), and E-cadherin aberrant subtype (integrated classification) presented the Lauren diffuse histology enrichment and tended to be diagnosed at a younger age. The MSI subtype was associated with a better overall survival across all classifications (TCGA, ACRG, and integrated classification). The worst prognosis was observed in the EBV subtype (TCGA and integrated classification) and MSS/EMT subtype (ACRG classification). Discussion/Conclusion . We reported a reproducible and affordable gastric cancer subtyping algorithms that can reproduce the recently recognized TCGA, ACRG, and integrated gastric cancer classifications, using techniques available in routine diagnosis. These simplified classifications can be employed not only for molecular classification but also in predicting the prognosis of gastric cancer patients.
Competing Interests: The authors have no conflicts of interest to declare.
(Copyright © 2021 Jean Paul Nshizirungu et al.)
References: Nat Med. 2015 May;21(5):449-56. (PMID: 25894828)
Br J Cancer. 2011 Jun 28;105(1):38-43. (PMID: 21654677)
J Hematol Oncol. 2019 May 31;12(1):54. (PMID: 31151482)
Infect Agent Cancer. 2017 Jul 19;12:41. (PMID: 28814970)
Braz J Microbiol. 2012 Jan;43(1):393-404. (PMID: 24031845)
Mod Pathol. 2016 Jul;29(7):772-84. (PMID: 27032689)
Gastroenterology. 2002 Dec;123(6):1804-11. (PMID: 12454837)
Genet Test Mol Biomarkers. 2021 Feb;25(2):116-123. (PMID: 33596142)
Gastroenterology. 2009 Sep;137(3):824-33. (PMID: 19445939)
Histopathology. 1999 Nov;35(5):477-8. (PMID: 10583566)
Cancer Treat Rev. 2018 May;66:15-22. (PMID: 29631196)
Lancet. 2010 Aug 28;376(9742):687-97. (PMID: 20728210)
Histopathology. 2008 Jun;52(7):797-805. (PMID: 18422971)
Clin Cancer Res. 2016 Feb 15;22(4):813-20. (PMID: 26880610)
Virchows Arch. 2018 Mar;472(3):369-382. (PMID: 29046940)
J Gastroenterol Hepatol. 2009 Mar;24(3):354-65. (PMID: 19335785)
Histopathology. 1999 May;34(5):410-5. (PMID: 10231415)
N Engl J Med. 2015 Jun 25;372(26):2509-20. (PMID: 26028255)
BMC Cancer. 2015 Oct 24;15:782. (PMID: 26498209)
Arch Toxicol. 2015 Jun;89(6):899-921. (PMID: 25701956)
Mod Pathol. 2011 Sep;24(9):1248-53. (PMID: 21552211)
Br J Surg. 2004 Apr;91(4):469-75. (PMID: 15048750)
Nature. 2014 Sep 11;513(7517):202-9. (PMID: 25079317)
Histopathology. 1994 Aug;25(2):101-11. (PMID: 7982672)
Cancer Manag Res. 2019 Jul 10;11:6397-6410. (PMID: 31372044)
Int J Cancer. 2019 Apr 15;144(8):1941-1953. (PMID: 30350310)
Gut. 2014 Feb;63(2):236-43. (PMID: 23580779)
Mol Med Rep. 2020 Aug;22(2):828-840. (PMID: 32468041)
J Surg Oncol. 2020 Apr;121(5):804-813. (PMID: 31797380)
Mol Clin Oncol. 2015 May;3(3):699-705. (PMID: 26137290)
PLoS One. 2019 Dec 2;14(12):e0224812. (PMID: 31790410)
J Gastrointest Oncol. 2012 Sep;3(3):251-61. (PMID: 22943016)
CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593)
Science. 2017 Jul 28;357(6349):409-413. (PMID: 28596308)
Cancer Med. 2015 Jan;4(1):75-83. (PMID: 25354498)
Int J Cancer. 1996 Jun 21;69(3):184-9. (PMID: 8682585)
Am J Surg Pathol. 2017 Jan;41(1):106-115. (PMID: 27819872)
المشرفين على المادة: 0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20210809 Date Completed: 20220105 Latest Revision: 20220425
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8342151
DOI: 10.1155/2021/9980410
PMID: 34367379
قاعدة البيانات: MEDLINE
الوصف
تدمد:1875-8630
DOI:10.1155/2021/9980410