دورية أكاديمية
أعرض في EDS

Prevalence of methicillin-resistant Staphylococcus aureus colonization among healthcare workers at a tertiary care hospital in northeastern Brazil.

التفاصيل البيبلوغرافية
العنوان: Prevalence of methicillin-resistant Staphylococcus aureus colonization among healthcare workers at a tertiary care hospital in northeastern Brazil.
المؤلفون: da Silva LSC; State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Ilhéus, Brazil.; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Andrade YMFS; State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Ilhéus, Brazil.; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Oliveira AC; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Cunha BC; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Oliveira EG; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Cunha TS; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Mafra SS; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Almeida JB; State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Ilhéus, Brazil.; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Carvalho SP; State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Ilhéus, Brazil., Nascimento FS; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Santos Junior MN; State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Ilhéus, Brazil.; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Chamon RC; Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.; Pathology Department, Medicine Faculty, Fluminense Federal University (UFF), Niterói, Brazil., Santos KRN; Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil., Campos GB; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil., Marques LM; State University of Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Ilhéus, Brazil.; Multidisciplinary Institute of Health, Federal University of Bahia (UFBA), Vitória da Conquista, Brazil.
المصدر: Infection prevention in practice [Infect Prev Pract] 2020 Aug 23; Vol. 2 (4), pp. 100084. Date of Electronic Publication: 2020 Aug 23 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101777928 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-0889 (Electronic) Linking ISSN: 25900889 NLM ISO Abbreviation: Infect Prev Pract Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Elsevier Ltd., [2019]-
مستخلص: Background: Staphylococcus aureus is a human pathogen of clinical importance related to a variety of infections.
Aim: The objective of this study was to analyze the molecular and epidemiological characteristics of S. aureus obtained from healthcare professionals (HCP) of a hospital in southwestern Bahia, Brazil.
Methods: Samples were collected from hands, nasal cavity, and laboratory coats of 80 HCP. The bacterial isolates recovered from 240 samples were identified as S. aureus, and then analyzed for their antimicrobial resistance profile, genotypic characterization, and pathogenicity.
Findings: 178 isolates were identified as S. aureus , being mostly isolated from the nasal cavity. Thirty isolates (16.8%) were characterized as MRSA. The virulence gene frequency varied according to isolate source. All virulence genes were identified in at least one hand isolate. Isolates from laboratory coats did not show seb and pvl. Isolates from the nasal cavity did not exhibit pvl. The SCCmec type I was identified in 56.7% of MRSA isolates. Among MRSA isolates, 14 PFGE pulsotypes were characterized, with profile A being predominant (nine isolates). Clonal complexes CC5, CC45, and CC398 were found. MRSA isolates induced cytokine gene expression in macrophages, with IL-10 and IL-17 being expressed more often.
Conclusion: We found a high colonization rate for S. aureus among HCP. Moreover, we observed that MRSA strains presented different virulence factors and could induce cytokine gene expression, indicating an urgent need to control colonization rates of HCP by MRSA isolates in order to protect hospital patients and the general public.
(© 2020 The Authors.)
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فهرسة مساهمة: Keywords: Gene expression; Genes of virulence; MRSA; Molecular epidemiology; Resistance; S. aureus
تواريخ الأحداث: Date Created: 20210809 Latest Revision: 20231107
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8336055
DOI: 10.1016/j.infpip.2020.100084
PMID: 34368723
قاعدة البيانات: MEDLINE
الوصف
تدمد:2590-0889
DOI:10.1016/j.infpip.2020.100084