دورية أكاديمية
In situ Tissue Regeneration in the Cornea from Bench to Bedside.
| العنوان: | In situ Tissue Regeneration in the Cornea from Bench to Bedside. |
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| المؤلفون: | Poudel BK; Département d'Ophtalmologie, Université de Montréal, Montréal, Québec, Canada.; Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada., Robert MC; Département d'Ophtalmologie, Université de Montréal, Montréal, Québec, Canada.; Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.; Département d'Opthalmologie, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada., Simpson FC; Département d'Ophtalmologie, Université de Montréal, Montréal, Québec, Canada.; Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.; Département d'Opthalmologie, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.; Institut du Génie Biomédicale, Université de Montréal, Montréal, Québec, Canada., Malhotra K; Département d'Ophtalmologie, Université de Montréal, Montréal, Québec, Canada.; Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.; Département d'Opthalmologie, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada., Jacques L; Département d'Ophtalmologie, Université de Montréal, Montréal, Québec, Canada.; Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada., LaBarre P; SightLife, Seattle, Washington, USA., Griffith M; Département d'Ophtalmologie, Université de Montréal, Montréal, Québec, Canada.; Centre de Recherche, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.; Département d'Opthalmologie, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada.; Institut du Génie Biomédicale, Université de Montréal, Montréal, Québec, Canada. |
| المصدر: | Cells, tissues, organs [Cells Tissues Organs] 2022; Vol. 211 (4), pp. 506-526. Date of Electronic Publication: 2021 Aug 11. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 100883360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1422-6421 (Electronic) Linking ISSN: 14226405 NLM ISO Abbreviation: Cells Tissues Organs Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, c1999- |
| مواضيع طبية MeSH: | Cornea*/physiology , Corneal Transplantation*, Biocompatible Materials/pharmacology ; Biocompatible Materials/therapeutic use ; Blindness ; Child ; Collagen/pharmacology ; Humans |
| مستخلص: | Corneal blindness accounts for 5.1% of visual deficiency and is the fourth leading cause of blindness globally. An additional 1.5-2 million people develop corneal blindness each year, including many children born with or who later develop corneal infections. Over 90% of corneal blind people globally live in low- and middle-income regions (LMIRs), where corneal ulcers are approximately 10-fold higher compared to high-income countries. While corneal transplantation is an effective option for patients in high-income countries, there is a considerable global shortage of corneal graft tissue and limited corneal transplant programs in many LMIRs. In situ tissue regeneration aims to restore diseases or damaged tissues by inducing organ regeneration. This can be achieved in the cornea using biomaterials based on extracellular matrix (ECM) components like collagen, hyaluronic acid, and silk. Solid corneal implants based on recombinant human collagen type III were successfully implanted into patients resulting in regeneration of the corneal epithelium, stroma, and sub-basal nerve plexus. As ECM crosslinking and manufacturing methods improve, the focus of biomaterial development has shifted to injectable, in situ gelling formulations. Collagen, collagen-mimetic, and gelatin-based in situ gelling formulas have shown the ability to repair corneal wounds, surgical incisions, and perforations in in-vivo models. Biomaterial approaches may not be sufficient to treat inflammatory conditions, so other cell-free therapies such as treatment with tolerogenic exosomes and extracellular vesicles may improve treatment outcomes. Overall, many of the technologies described here show promise as future medical devices or combination products with cell or drug-based therapies. In situ tissue regeneration, particularly with liquid formulas, offers the ability to triage and treat corneal injuries and disease with a single regenerative solution, providing alternatives to organ transplantation and improving patient outcomes. (© 2021 S. Karger AG, Basel.) |
| معلومات مُعتمدة: | Canada CIHR |
| فهرسة مساهمة: | Keywords: Biomaterials; Clinical trial; Cornea; Exosomes; Regeneration; Regulatory considerations; Transplantation |
| المشرفين على المادة: | 0 (Biocompatible Materials) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20210811 Date Completed: 20220908 Latest Revision: 20220921 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000514690 |
| PMID: | 34380144 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-6421 |
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| DOI: | 10.1159/000514690 |