دورية أكاديمية
Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes.
العنوان: | Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes. |
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المؤلفون: | de Jong RM; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Meerstein-Kessel L; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Center for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, The Netherlands., Da DF; Institut de Recherche en Sciences de la Santé, Direction Régionale, Bobo Dioulasso, Burkina Faso., Nsango S; Malaria Research Laboratory, OCEAC, Yaoundé, Cameroon.; Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon., Challenger JD; Medical Research Council Centre for Global Infections Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK., van de Vegte-Bolmer M; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., van Gemert GJ; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., Duarte E; EPPIcenter Research Program, Division of HIV, ID, and Global Medicine, Department of Medicine, University of California, San Francisco, CA, USA., Teyssier N; EPPIcenter Research Program, Division of HIV, ID, and Global Medicine, Department of Medicine, University of California, San Francisco, CA, USA., Sauerwein RW; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; TropIQ Health Sciences, Nijmegen, Netherlands., Churcher TS; Medical Research Council Centre for Global Infections Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK., Dabire RK; Institut de Recherche en Sciences de la Santé, Direction Régionale, Bobo Dioulasso, Burkina Faso., Morlais I; Malaria Research Laboratory, OCEAC, Yaoundé, Cameroon.; MIVEGEC, Université Montpellier, IRD, CNRS, Montpellier, France., Locke E; PATH's Malaria Vaccine Initiative, Washington, DC, USA., Huynen MA; Center for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, The Netherlands., Bousema T; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Teun.bousema@radboudumc.nl., Jore MM; Department of Medical Microbiology and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Matthijs.jore@radboudumc.nl. |
المصدر: | NPJ vaccines [NPJ Vaccines] 2021 Aug 12; Vol. 6 (1), pp. 101. Date of Electronic Publication: 2021 Aug 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]- |
مستخلص: | Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (mAbs) target sexual stage antigens to interrupt human-to-mosquito transmission and may form important tools for malaria elimination. Although most epitopes of these antigens are considered highly conserved, little is known about the impact of natural genetic diversity on the functional activity of transmission-blocking antibodies. Here we measured the efficacy of three mAbs against leading TBV candidates (Pfs48/45, Pfs25 and Pfs230) in transmission assays with parasites from naturally infected donors compared to their efficacy against the strain they were raised against (NF54). Transmission-reducing activity (TRA) was measured as reduction in mean oocyst intensity. mAb 45.1 (α-Pfs48/45) and mAb 4B7 (α-Pfs25) reduced transmission of field parasites from almost all donors with IC (© 2021. The Author(s).) |
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معلومات مُعتمدة: | MR/R015600/1 RCUK | Medical Research Council (MRC); MR/R015600/1 RCUK | Medical Research Council (MRC); 192.061 Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) |
تواريخ الأحداث: | Date Created: 20210813 Latest Revision: 20240403 |
رمز التحديث: | 20240403 |
مُعرف محوري في PubMed: | PMC8361195 |
DOI: | 10.1038/s41541-021-00366-9 |
PMID: | 34385463 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2059-0105 |
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DOI: | 10.1038/s41541-021-00366-9 |