دورية أكاديمية
Clinical significance of P-class pumps in cancer.
العنوان: | Clinical significance of P-class pumps in cancer. |
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المؤلفون: | Themistocleous SC; Department of Medicine, School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus., Yiallouris A; Department of Medicine, School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus., Tsioutis C; Department of Medicine, School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus., Zaravinos A; Department of Life Sciences, School of Sciences, European University Cyprus, 2404 Nicosia, Cyprus.; College of Medicine, Member of Qatar University Health, Qatar University, 2713 Doha, Qatar., Johnson EO; Department of Medicine, School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus., Patrikios I; Department of Medicine, School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus. |
المصدر: | Oncology letters [Oncol Lett] 2021 Sep; Vol. 22 (3), pp. 658. Date of Electronic Publication: 2021 Jul 12. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Spandidos Publications] Country of Publication: Greece NLM ID: 101531236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1792-1082 (Electronic) Linking ISSN: 17921074 NLM ISO Abbreviation: Oncol Lett Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Athens : Spandidos Publications] |
مستخلص: | P-class pumps are specific ion transporters involved in maintaining intracellular/extracellular ion homeostasis, gene transcription, and cell proliferation and migration in all eukaryotic cells. The present review aimed to evaluate the role of P-type pumps [Na + /K + ATPase (NKA), H + /K + ATPase (HKA) and Ca2 + -ATPase] in cancer cells across three fronts, namely structure, function and genetic expression. It has been shown that administration of specific P-class pumps inhibitors can have different effects by: i) Altering pump function; ii) inhibiting cell proliferation; iii) inducing apoptosis; iv) modifying metabolic pathways; and v) induce sensitivity to chemotherapy and lead to antitumor effects. For example, the NKA β2 subunit can be downregulated by gemcitabine, resulting in increased apoptosis of cancer cells. The sarcoendoplasmic reticulum calcium ATPase can be inhibited by thapsigargin resulting in decreased prostate tumor volume, whereas the HKA α subunit can be affected by proton pump inhibitors in gastric cancer cell lines, inducing apoptosis. In conclusion, the present review highlighted the central role of P-class pumps and their possible use and role as anticancer cellular targets for novel therapeutic chemical agents. Competing Interests: The authors declare that they have no competing interests. (Copyright: © Themistocleous et al.) |
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فهرسة مساهمة: | Keywords: HKA; NKA; P-type ATPases; SERCA; cancer; pump subunits |
تواريخ الأحداث: | Date Created: 20210813 Latest Revision: 20210814 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8298992 |
DOI: | 10.3892/ol.2021.12919 |
PMID: | 34386080 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1792-1082 |
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DOI: | 10.3892/ol.2021.12919 |