دورية أكاديمية
Prolonged blood coagulation time among occupationally exposed automobile technicians in Abeokuta, Nigeria.
| العنوان: | Prolonged blood coagulation time among occupationally exposed automobile technicians in Abeokuta, Nigeria. |
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| المؤلفون: | Akinwande KS; Department of Chemical Pathology and Immunology, 557715Federal Medical Centre, Abeokuta, Nigeria., Olateru-Olagbegi O; Department of Haematology and Blood Transfusion, 107962University College Hospital, Ibadan, Nigeria., Okwor CJ; Department of Chemical Pathology, 291413University of Nigeria Teaching Hospital, Enugu, Nigeria., Uche CZ; Department of Medical Biochemistry & Molecular Biology, College of Medicine, 107769University of Nigeria, Nigeria., Eni BB; Department of Internal Medicine, 107769University College Hospital, Ibadan, Nigeria., Edem VF; Department of Immunology, University of Ibadan, Ibadan, Nigeria. |
| المصدر: | Toxicology and industrial health [Toxicol Ind Health] 2021 Sep; Vol. 37 (9), pp. 528-534. Date of Electronic Publication: 2021 Aug 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 8602702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0393 (Electronic) Linking ISSN: 07482337 NLM ISO Abbreviation: Toxicol Ind Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Princeton, N.J. : Princeton Scientific Pub. Co. |
| مواضيع طبية MeSH: | Automobiles*, Blood Coagulation/*drug effects , Blood Coagulation Disorders/*chemically induced , Metals, Heavy/*adverse effects , Occupational Exposure/*adverse effects, Adult ; Copper/adverse effects ; Copper/blood ; Humans ; Lead/adverse effects ; Lead/blood ; Logistic Models ; Male ; Metals, Heavy/blood ; Nigeria ; Partial Thromboplastin Time ; Prothrombin Time ; Zinc/adverse effects ; Zinc/blood |
| مستخلص: | Automobile technicians in resource-poor settings often work in poor environments and are exposed to chemicals that put them at risk of ill health and disease. These chemical exposures could affect blood coagulation, leading to bleeding disorders or thrombosis. The present study is aimed at assessing prothrombin test (PT) and activated partial thromboplastin test (aPTT) values, serum zinc (Zn) and copper (Cu) concentrations, and blood lead level (BLL) among occupationally exposed automobile technicians compared to unexposed controls. A total of 140 consenting participants comprising 70 automobile technicians and 70 unexposed controls were recruited for this case-control study. A 6-mL blood sample was drawn from each participant for estimation of BLL, serum Zn and Cu concentrations, and PT and aPTT values. Blood lead level, and serum Zn and Cu concentrations were determined using atomic absorption spectrophotometry, while PT and aPTT values were determined using Innovin PT and Actin FS Activated PTT reagents on the Sysmex CA-101 coagulation analyser. Data were analysed using t-tests, chi-square tests, and logistic and multiple linear regression analyses with statistical significance set at p < 0.05. The mean BLL, serum Zn concentration, and PT and aPTT values were significantly higher in automobile technicians compared to controls. Binary logistic regression showed that automobile technicians had higher odds of elevated PT value (OR = 21.769; p = 0.000), aPTT value (OR = 1.348; p = 0.018), BLL (OR = 1.261; p = 0.000) and serum Zn concentration (OR = 1.063; p = 0.005) than unexposed controls. Linear regression showed significant positive association of PT value with BLL and with serum Zn concentration. Higher PT and aPTT values reflect prolonged blood coagulation time among automobile technicians, which indicates impairment of extrinsic and intrinsic coagulation pathways associated with work-related exposures. |
| فهرسة مساهمة: | Keywords: Automobile technician; activated partial thromboplastin test; blood lead level; copper; occupational exposure; prothrombin test; zinc |
| المشرفين على المادة: | 0 (Metals, Heavy) 2P299V784P (Lead) 789U1901C5 (Copper) J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20210814 Date Completed: 20220113 Latest Revision: 20220113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/07482337211030425 |
| PMID: | 34388958 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0393 |
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| DOI: | 10.1177/07482337211030425 |