دورية أكاديمية
أعرض في EDS

Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.

التفاصيل البيبلوغرافية
العنوان: Influence of thyroid hormone in the expression of the marker pro-apoptosis BID, in spite of the predominance of anti-apoptosis activation in intratiroidal lymphocytic infiltration in Hashimoto's thyroiditis.
المؤلفون: Vasconcelos JC; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil. Electronic address: jessicacastro@gmail.com., Siqueira IB; Department of Pathology, School of Medical Sciences, University of Campinas, São Paulo, Brazil. Electronic address: icleiabarreto@gmail.com., Maia FFR; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil. Electronic address: drfredericomaia@gmail.com., Parisi MCR; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil. Electronic address: candidap@unicamp.br., Zantut-Wittmann DE; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil. Electronic address: zantutw@unicamp.br.
المصدر: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2021 Nov 01; Vol. 537, pp. 111421. Date of Electronic Publication: 2021 Aug 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : North Holland Publishing
Original Publication: Amsterdam, North-Holland.
مواضيع طبية MeSH: Apoptosis*/drug effects, BH3 Interacting Domain Death Agonist Protein/*metabolism , Hashimoto Disease/*immunology , Hashimoto Disease/*pathology , Lymphocytes/*immunology , Thyroid Hormones/*pharmacology, Adult ; Aged ; Biomarkers/metabolism ; Cell Proliferation/drug effects ; Female ; Hashimoto Disease/physiopathology ; Humans ; Ki-67 Antigen/metabolism ; Lymphocytes/drug effects ; Middle Aged ; Organ Size/drug effects ; Young Adult
مستخلص: Cell destruction in Hashimoto's thyroiditis (HT) involves autoantibodies and cytotoxic T lymphocytes. Thyrocytes maintenance occurs by pro-apoptotic, anti-apoptotic and cell proliferation balance.
Objectives: To characterize factors related to the mechanisms of apoptosis and cell proliferation in thyroid cells and intrathyroid lymphocytic infiltrate in HT.
Methods: We assessed lymphocytic infiltrate and thyroid cells from HT and normal thyroid by immunohistochemical analysis of cell proliferation (Ki-67), antiproliferation (p27Kip1), pro-apoptosis (Fas, Fas-ligand, BID) and anti-apoptosis (MCL-1, BCL2) markers.
Results: Lymphocytic infiltrate presented BCL2 and MCL-1 higher expression, Ki-67 and p27kip1 balance. Thyrocytes exhibited Fas and FasL balance, higher BID expression; MCL-1, BCL-2, Ki-67 similar to the normal thyroid. T4 and higher lymphocytes BID expression were associated.
Conclusions: In lymphocytic infiltrate predominated anti-apoptosis in relation to pro-apoptosis except for BID. Thyrocytes presented pro-apoptosis and anti-apoptosis balance and cell proliferation similar to normal thyroid. T4-associated BID expression in HT lymphocytes suggests the influence of thyroid hormone as a signal to up-regulate the BID pro-apoptotic protein and thus increase lymphocytic apoptosis rates.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Apoptosis; Autoimmune thyroiditis; Cell proliferation; Hashimoto’ thyroiditis
المشرفين على المادة: 0 (BH3 Interacting Domain Death Agonist Protein)
0 (Biomarkers)
0 (Ki-67 Antigen)
0 (Thyroid Hormones)
تواريخ الأحداث: Date Created: 20210814 Date Completed: 20220321 Latest Revision: 20220321
رمز التحديث: 20231215
DOI: 10.1016/j.mce.2021.111421
PMID: 34389447
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8057
DOI:10.1016/j.mce.2021.111421