دورية أكاديمية
Nickel sulfate exposure induces ovarian inflammation and fibrosis and decreases oocyte quality in mice.
| العنوان: | Nickel sulfate exposure induces ovarian inflammation and fibrosis and decreases oocyte quality in mice. |
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| المؤلفون: | Zhao SC; Medical College, Guangxi University, Nanning, Guangxi 530004, China., Xu ZR; Translational Medicine Research Center, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China., Xu CL; Reproductive Medical Center of Nanning Second People's Hospital, Nanning, Guangxi 530031, China., He QK; Medical College, Guangxi University, Nanning, Guangxi 530004, China., Yang GM; College of Life Science and Technology, Guangxi University, Nanning, Guangxi 530004, China., Li YP; College of Life Science and Technology, Guangxi University, Nanning, Guangxi 530004, China., Luo YS; Medical College, Guangxi University, Nanning, Guangxi 530004, China., Wang HL; Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China., Qi ZQ; Medical College, Guangxi University, Nanning, Guangxi 530004, China. Electronic address: yxyyz@gxu.edu.cn., Liu Y; Medical College, Guangxi University, Nanning, Guangxi 530004, China. Electronic address: liuyu@gxu.edu.cn. |
| المصدر: | Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Aug 13; Vol. 224, pp. 112634. Date of Electronic Publication: 2021 Aug 13. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Netherlands : Elsevier |
| مستخلص: | Nickel is a heavy metal element extensively distributed in the environment and widely used in modern life. Divalent nickel is one of the most widespread forms of nickel and has been reported as toxic to various tissues. However, whether exposure to divalent nickel negatively affects ovarian homeostasis and oocyte quality remains unclear. In this study, we found that 3 weeks of nickel sulfate exposure affected body growth and decreased the weight and coefficient of the ovary, and increased atretic follicles exhibiting enhanced apoptosis in granulosa cells. Further studies have found that nickel sulfate triggered ovarian fibrosis and inflammation via transforming growth factor-β1 and nuclear factor-κB pathways, and reduced oocyte development ability. In addition, nickel sulfate increased the level of reactive oxygen species, which induced DNA damage and early apoptosis. Moreover, it was found that nickel sulfate caused damage to the mitochondria showing aberrant morphology, distribution and membrane potential while decreased levels of histone methylation. To summarize, our results indicated that nickel sulfate exposure triggered ovarian fibrosis and inflammation and caused structural and functional disorders of mitochondria in oocytes, which consequently disturbed ovarian homeostasis and follicle development and decreased oocyte quality. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Fibrosis; Follicle; Inflammation; Mitochondria; Oocyte |
| تواريخ الأحداث: | Date Created: 20210815 Latest Revision: 20240220 |
| رمز التحديث: | 20240221 |
| DOI: | 10.1016/j.ecoenv.2021.112634 |
| PMID: | 34392153 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2414 |
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| DOI: | 10.1016/j.ecoenv.2021.112634 |