دورية أكاديمية
Ultrastructural immunocytochemical distribution of tubulin in cultured cells treated with microtubule inhibitors.
| العنوان: | Ultrastructural immunocytochemical distribution of tubulin in cultured cells treated with microtubule inhibitors. |
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| المؤلفون: | De Brabander M, De May J, Joniau M, Geuens G |
| المصدر: | Cell biology international reports [Cell Biol Int Rep] 1977 Mar; Vol. 1 (2), pp. 177-83. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published for the International Federation for Cell Biology by Academic Press Country of Publication: England NLM ID: 7708050 Publication Model: Print Cited Medium: Print ISSN: 0309-1651 (Print) Linking ISSN: 03091651 NLM ISO Abbreviation: Cell Biol Int Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, New York, Published for the International Federation for Cell Biology by Academic Press. |
| مواضيع طبية MeSH: | Cytoplasm/*analysis , Glycoproteins/*analysis , Microtubules/*drug effects , Tubulin/*analysis, Benzimidazoles/pharmacology ; Carbamates/pharmacology ; Cell Line ; Colchicine/pharmacology ; Immunoenzyme Techniques ; Microtubules/analysis ; Mitosis ; Vinblastine/pharmacology |
| مستخلص: | Microtubules in tissue cultured cells are stained immunocytochemically with the PAP-method using a purified antitubulin antibody. Treatment of the cells with microtubule inhibitors (colchicine, nocodazole, vinblastine) results in the disappearance of microtubules. The diffuse cytoplasmic staining is strongly increased in the cells by colchicine and nocodazole. Vinblastine produces paracrystalline aggregates that are strongly stained and macrotubules that are unstained. The diffuse staining is much less in vinblastine-treated cells. The bundles of intermediate filaments that are induced by all microtubule inhibitors do not bind the antitubulin antibody. |
| المشرفين على المادة: | 0 (Benzimidazoles) 0 (Carbamates) 0 (Glycoproteins) 0 (Tubulin) 5V9KLZ54CY (Vinblastine) SML2Y3J35T (Colchicine) |
| تواريخ الأحداث: | Date Created: 19770301 Date Completed: 19780524 Latest Revision: 20190911 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/0309-1651(77)90038-8 |
| PMID: | 343926 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0309-1651 |
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| DOI: | 10.1016/0309-1651(77)90038-8 |