دورية أكاديمية
Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells.
العنوان: | Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells. |
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المؤلفون: | Astorga-Gamaza A; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Vitali M; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Borrajo ML; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Suárez-López R; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain., Jaime C; Departament de Química, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain., Bastus N; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain., Serra-Peinado C; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Luque-Ballesteros L; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Blanch-Lombarte O; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain., Prado JG; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain., Lorente J; Otorhinolaryngology Department, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain., Pumarola F; Otorhinolaryngology Department, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain., Pellicer M; Otorhinolaryngology Department, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain., Falcó V; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Genescà M; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Puntes V; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain., Buzon MJ; Infectious Disease Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. |
المصدر: | Nano today [Nano Today] 2021 Feb; Vol. 36. Date of Electronic Publication: 2020 Dec 20. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101297352 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1748-0132 (Print) Linking ISSN: 17480132 NLM ISO Abbreviation: Nano Today Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Kidlington, UK : Elsevier Ltd. |
مستخلص: | HIV represents a persistent infection which negatively alters the immune system. New tools to reinvigorate different immune cell populations to impact HIV are needed. Herein, a novel nanotool for the specific enhancement of the natural killer (NK) immune response towards HIV-infected T-cells has been developed. Bispecific Au nanoparticles (BiAb-AuNPs), dually conjugated with IgG anti-HIVgp120 and IgG anti-human CD16 antibodies, were generated by a new controlled, linker-free and cooperative conjugation method promoting the ordered distribution and segregation of antibodies in domains. The cooperatively-adsorbed antibodies fully retained the capabilities to recognize their cognate antigen and were able to significantly enhance cell-to-cell contact between HIV-expressing cells and NK cells. As a consequence, the BiAb-AuNPs triggered a potent cytotoxic response against HIV-infected cells in blood and human tonsil explants. Remarkably, the BiAb-AuNPs were able to significantly reduce latent HIV infection after viral reactivation in a primary cell model of HIV latency. This novel molecularly-targeted strategy using a bispecific nanotool to enhance the immune system represents a new approximation with potential applications beyond HIV. |
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معلومات مُعتمدة: | R21 AI118411 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Bispecific nanoparticles; HIV; NK cells; Polarization |
تواريخ الأحداث: | Date Created: 20210816 Latest Revision: 20210817 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8360327 |
DOI: | 10.1016/j.nantod.2020.101056 |
PMID: | 34394703 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1748-0132 |
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DOI: | 10.1016/j.nantod.2020.101056 |