دورية أكاديمية
Circulating chemerin levels in women with polycystic ovary syndrome: a meta-analysis.
| العنوان: | Circulating chemerin levels in women with polycystic ovary syndrome: a meta-analysis. |
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| المؤلفون: | Wang X; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Zhang Q; Department of Obstetrics and Gynecology, The First Affiliated Hospital, Medical School of the Air Force Medical University, Xi'an, China., Zhang L; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Wei W; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Liu L; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Li B; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Zhang L; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Zhang Y; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Hui Y; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China., Lei Y; Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Medical School of Shanxi University of Traditional Chinese Medicine, Xianyang, China. |
| المصدر: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2022 Jan; Vol. 38 (1), pp. 22-27. Date of Electronic Publication: 2021 Aug 17. |
| نوع المنشور: | Journal Article; Meta-Analysis |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Carnforth, Lancashire ; Park Ridge, N.J.] : Parthenon Pub., [c1987- |
| مواضيع طبية MeSH: | Chimerin Proteins/*blood , Polycystic Ovary Syndrome/*blood, Female ; Humans ; Regression Analysis |
| مستخلص: | Objective: The present meta-analysis was conducted to investigate the association between circulating chemerin levels and polycystic ovary syndrome (PCOS) in women. Methods: Relevant studies published up to May 2020 were searched from PubMed, Ovid, the Cochrane Library, and Clinical Trial Database. A random effects model was used to measure the strength of association between PCOS and chemerin by using the standardized mean difference (SMD) and 95% confidence interval (CI). All data were analyzed using Stata 12.0 (version 12; Stata-Corp, College Station, TX). Results: The final meta-analysis included eight studies with 15 results including a total of 897 participants (524 patients with PCOS and 373 controls). The circulating chemerin levels were higher in patients with PCOS (random effects SMD = 1.07; 95% CI: 0.55-1.59; p < .001) than in controls. However, considerable heterogeneity across studies was not eliminated in subgroup analyses. The meta-regression analysis further suggested that region is the main source of heterogeneity ( p = .001). Conclusions: Our meta-analysis indicated that women with PCOS have significantly higher circulating chemerin levels than in healthy women, indicating that chemerin may be involved in the pathogenesis of PCOS. |
| فهرسة مساهمة: | Keywords: Chemerin; adipokine; homeostatic model assessment of insulin resistance; inflammation; meta-analysis; polycystic ovary syndrome |
| المشرفين على المادة: | 0 (Chimerin Proteins) |
| تواريخ الأحداث: | Date Created: 20210817 Date Completed: 20220318 Latest Revision: 20220429 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/09513590.2021.1963431 |
| PMID: | 34402730 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1473-0766 |
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| DOI: | 10.1080/09513590.2021.1963431 |