دورية أكاديمية
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification.
| العنوان: | Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification. |
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| المؤلفون: | Baker YR; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Yuan L; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Chen J; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Belle R; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK., Carlisle R; Institute of Biomedical Engineering, University of Oxford, Oxford, OX3 7DQ, UK., El-Sagheer AH; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.; Chemistry Branch Department of Science and Mathematics, Suez University, Suez 43721, Egypt., Brown T; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. |
| المصدر: | Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9042-9052. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1992- : Oxford : Oxford University Press Original Publication: London, Information Retrieval ltd. |
| مواضيع طبية MeSH: | DNA/*chemistry , Nanostructures/*chemistry , Nucleic Acid Amplification Techniques/*methods, Aptamers, Peptide/chemistry ; Cell Line, Tumor ; Cycloaddition Reaction/methods ; Humans |
| مستخلص: | Rolling circle amplification (RCA) is a powerful tool for the construction of DNA nanomaterials such as hydrogels, high-performance scaffolds and DNA nanoflowers (DNFs), hybrid materials formed of DNA and magnesium pyrophosphate. Such DNA nanomaterials have great potential in therapeutics, imaging, protein immobilisation, and drug delivery, yet limited chemistry is available to expand their functionality. Here, we present orthogonal strategies to produce densely modified RCA products and DNFs. We provide methods to selectively modify the DNA component and/or the protein cargo of these materials, thereby greatly expanding the range of chemical functionalities available to these systems. We have used our methodology to construct DNFs bearing multiple surface aptamers and peptides capable of binding to cancer cells that overexpress the HER2 oncobiomarker, demonstrating their potential for diagnostic and therapeutic applications. (© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.) |
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| معلومات مُعتمدة: | BB/J001694/2 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/ R008655/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| المشرفين على المادة: | 0 (Aptamers, Peptide) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20210817 Date Completed: 20211108 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC8450075 |
| DOI: | 10.1093/nar/gkab720 |
| PMID: | 34403467 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1362-4962 |
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| DOI: | 10.1093/nar/gkab720 |