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Case Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic ® Software.

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العنوان: Case Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic ® Software.
المؤلفون: Saldarreaga Marin A; Bahía de Cádiz-La Janda Health District, Mobile Emergency Unit of the Andalusian Health Care, Service of Cádiz, Cádiz, Spain., Cendros M; Eugenomic, Barcelona, Spain., Ciudad CJ; Biochemistry and Molecular Biology Unit, School of Pharmacy, University of Barcelona, Barcelona, Spain., Sabater A; Eugenomic, Barcelona, Spain.
المصدر: Pharmacogenomics and personalized medicine [Pharmgenomics Pers Med] 2021 Aug 12; Vol. 14, pp. 963-970. Date of Electronic Publication: 2021 Aug 12 (Print Publication: 2021).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101514107 Publication Model: eCollection Cited Medium: Print ISSN: 1178-7066 (Print) Linking ISSN: 11787066 NLM ISO Abbreviation: Pharmgenomics Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Auckland, New Zealand : Dove Medical Press
مستخلص: This was a case report of severe fatigue and bleeding in a 65-year-old man with ischemic heart disease who was wearing a stent and taking multiple medications for hypertension and diabetes. The use of a drug interaction and personalized prescription software (g-Nomic ® ) revealed potential interactions, involving acetylsalicylic acid and several non-pharmaceutical products including ginger, blueberry extracts, pineapple juice, docosahexaenoic acid and liquorice. Correction of these interactions resulted in complete remission of the reported side effects. This supports the idea that non-pharmaceuticals potentiated the effects of acetylsalicylic acid on haemostasis, producing the bleeding that would have caused fatigue. It is important to use appropriate tools to detect drug interactions that also take into account commonly used non-pharmaceutical products. Drug interactions can be considered illnesses by themselves.
Competing Interests: Marc Cendrós and Ana Sabater work for EUGENOMIC S.L. and are directly involved in the development of the g-Nomic® the personalized prescription software, but neither they nor anyone at Eugenomic has had any role in the management and clinical evaluation of this case beyond assisting the medical professionals in using the software. In addition, Mrs Ana Sabater has a patent g-Nomic issued to Eugenomic. The authors declare no other conflicts of interest in this work.
(© 2021 Saldarreaga Marin et al.)
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فهرسة مساهمة: Keywords: SNP; bleeding; drug-drug interaction; drug-herb; drug-lifestyle interactions; fatigue; medication risk; personalized prescription; pharmacogenetics; pharmacogenetics software; polymedication; software
تواريخ الأحداث: Date Created: 20210819 Latest Revision: 20210820
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8367204
DOI: 10.2147/PGPM.S323463
PMID: 34408471
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-7066
DOI:10.2147/PGPM.S323463