دورية أكاديمية
أعرض في EDS

The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling.

التفاصيل البيبلوغرافية
العنوان: The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling.
المؤلفون: Alasady MJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA., Terry AR; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA., Pierce AD; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America., Cavalier MC; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America., Blaha CS; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA., Adipietro KA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America., Wilder PT; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, United States of America., Weber DJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, United States of America., Hay N; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA.
المصدر: PloS one [PLoS One] 2021 Aug 19; Vol. 16 (8), pp. e0256238. Date of Electronic Publication: 2021 Aug 19 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Interleukin-6/*genetics , Melanoma/*genetics , Ribosomal Protein S6 Kinases, 90-kDa/*genetics , S100 Calcium Binding Protein beta Subunit/*genetics , STAT3 Transcription Factor/*genetics, Calcium-Binding Proteins/genetics ; Cell Line, Tumor ; Cyclic AMP Response Element-Binding Protein/genetics ; Cytoplasm/genetics ; Doxycycline/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Signal Transduction/drug effects
مستخلص: S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling. Our results showed that S100B affects IL6 expression transcriptionally. S100B was shown to form a calcium-dependent protein complex with the p90 ribosomal S6 kinase (RSK), which in turn sequesters RSK into the cytoplasm. Consistently, S100B inhibition was found to restore phosphorylation of a nuclear located RSK substrate, CREB, which is a potent transcription factor for IL6 expression. Thus, elevated S100B reduces IL6-STAT3 signaling via RSK signaling pathway in malignant melanoma. Indeed, the elevated S100B levels in malignant melanoma cell lines correspond to low levels of IL6 and p-STAT3.
Competing Interests: NO authors have competing interests.
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معلومات مُعتمدة: F30 CA225058 United States CA NCI NIH HHS; F30 CA228191 United States CA NCI NIH HHS; R01 GM129327 United States GM NIGMS NIH HHS; R01 CA107331 United States CA NCI NIH HHS; T32 CA154274 United States CA NCI NIH HHS
المشرفين على المادة: 0 (CREB1 protein, human)
0 (Calcium-Binding Proteins)
0 (Cyclic AMP Response Element-Binding Protein)
0 (Interleukin-6)
0 (S100 Calcium Binding Protein beta Subunit)
0 (S100B protein, human)
0 (STAT3 Transcription Factor)
0 (STAT3 protein, human)
EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 90-kDa)
N12000U13O (Doxycycline)
تواريخ الأحداث: Date Created: 20210819 Date Completed: 20211209 Latest Revision: 20240506
رمز التحديث: 20240506
مُعرف محوري في PubMed: PMC8376063
DOI: 10.1371/journal.pone.0256238
PMID: 34411141
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0256238