دورية أكاديمية
أعرض في EDS

Risk factors of fetal deaths and major birth defects in newborns of women with epilepsy: An Egyptian prospective study.

التفاصيل البيبلوغرافية
العنوان: Risk factors of fetal deaths and major birth defects in newborns of women with epilepsy: An Egyptian prospective study.
المؤلفون: Hosny H; Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt., Elkattan M; Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt., Zaki MA; Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt., Ramzy GM; Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt., Magdy R; Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: rehab.m.hassan@kasralainy.edu.eg., Abo Al-Azayem S; Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
المصدر: Epilepsy & behavior : E&B [Epilepsy Behav] 2021 Oct; Vol. 123, pp. 108251. Date of Electronic Publication: 2021 Aug 17.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Diego, CA : Academic Press, c2000-
مواضيع طبية MeSH: Epilepsy*/drug therapy , Epilepsy*/epidemiology , Pregnancy Complications*/drug therapy , Pregnancy Complications*/epidemiology, Adult ; Anticonvulsants/therapeutic use ; Egypt/epidemiology ; Female ; Fetal Death ; Humans ; Infant, Newborn ; Pregnancy ; Prospective Studies ; Risk Factors ; Young Adult
مستخلص: Objectives: Pregnancy registries for women with epilepsy (WWE) are arising all over the world. The aim of this work was to assess the risk factors of pregnancy losses and major birth defects (MBDs) of WWE through the Egyptian Registry of Anti-seizure medications and Pregnancy system.
Methods: An observational prospective study was conducted over 24 months (2018-2020). The following data were assessed: seizure control during pregnancy, Anti-seizure medications (ASMs) regimen, folic acid supplementation, and birth outcome.
Results: This study included 211 pregnant WWE, with mean age of 27.30 ± 5.51 years. One hundred eighty-six (89.9%) patients were on ASMs, from which 110 (59.1%) patients were on monotherapy. One hundred sixty-nine (80.0%) had healthy living babies, while fetal deaths occurred in 27 patients (12.8%) (25 abortions and 2 stillbirth), two patients (1%) had neonatal deaths, while 13 patients (6.2%) had living babies with MBDs. Although taking folic acid in the first trimester was a protective of fetal deaths (RR < 1, P 0.011), it was not a protective of MBDs. Seizure freedom during the entire pregnancy regardless of seizure type was another protective factor against fetal deaths (RR < 1, P < 0.001). Polytherapy exposure significantly increased the risk of MBDs compared with monotherapies (RR > 1, P 0.014). History of previous MBD was another risk factor of MBDs (RR > 1, P 0.027).
Conclusion: History of previous MBD and polytherapy exposure increased the risk of MBDs. Taking folic acid during first trimester and being seizure free during pregnancy were protective factors against fetal deaths.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Folic acid; Polytherapy; Pregnancy; Teratogenicity; Women with epilepsy
المشرفين على المادة: 0 (Anticonvulsants)
تواريخ الأحداث: Date Created: 20210819 Date Completed: 20211025 Latest Revision: 20211025
رمز التحديث: 20240628
DOI: 10.1016/j.yebeh.2021.108251
PMID: 34411949
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-5069
DOI:10.1016/j.yebeh.2021.108251