دورية أكاديمية
Conventional and microwave-assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids.
| العنوان: | Conventional and microwave-assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids. |
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| المؤلفون: | Desai NC; Division of Medicinal Chemistry, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, India., Bhatt K; Division of Medicinal Chemistry, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, India., Jadeja DJ; Division of Medicinal Chemistry, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, India., Mehta HK; Division of Medicinal Chemistry, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, India., Khedkar VM; School of Pharmacy, Vishwakarma University, Pune, India., Sarkar D; Combichem Bio-resource Centre, CSIR-National Chemical Laboratory, Pune, India. |
| المصدر: | Drug development research [Drug Dev Res] 2022 Apr; Vol. 83 (2), pp. 416-431. Date of Electronic Publication: 2021 Aug 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York : Alan R. Liss, c1981- |
| مواضيع طبية MeSH: | Mycobacterium tuberculosis* , Tuberculosis*/drug therapy, Antitubercular Agents/chemistry ; Chemistry Techniques, Synthetic ; Furans/pharmacology ; Furans/therapeutic use ; Humans ; Microbial Sensitivity Tests ; Microwaves ; Molecular Docking Simulation ; Pyridines/pharmacology ; Structure-Activity Relationship |
| مستخلص: | Drug resistance in tuberculosis poses a serious threat to humanity because currently available antitubercular drugs are ineffective against Mycobacterium tuberculosis (M. tuberculosis). As a result, the approval of Bedaquiline and Delamanid for the treatment of drug-resistant tuberculosis was accelerated. Still, there is an urgent need to search for new antitubercular drugs with novel mechanisms of action (MoA). Due to this, we have designed a synthetic strategy by utilizing microwave-assisted organic synthesis. We have compared our method with the conventional procedure, and the data show that our procedure is more effective in the preparation of title compounds. A unique series of 1-(2-(furan-2-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(aryl)-prop-2-en-1-ones (5a-o) was synthesized utilizing conventional and microwave-assisted techniques. Synthetic compounds were investigated for antitubercular activity against Mycobacterium TB H (© 2021 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: antitubercular activity; microwave-assisted organic synthesis; molecular docking |
| المشرفين على المادة: | 0 (Antitubercular Agents) 0 (Furans) 0 (Pyridines) |
| تواريخ الأحداث: | Date Created: 20210820 Date Completed: 20220502 Latest Revision: 20220524 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/ddr.21872 |
| PMID: | 34414591 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-2299 |
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| DOI: | 10.1002/ddr.21872 |