دورية أكاديمية
أعرض في EDS

Efficacy of a hypolipid diet in patients with primary antiphospholipid syndrome with dyslipidemia: a prospective study.

التفاصيل البيبلوغرافية
العنوان: Efficacy of a hypolipid diet in patients with primary antiphospholipid syndrome with dyslipidemia: a prospective study.
المؤلفون: Rodrigues TCR; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., de Oliveira Vaz C; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., Miranda ECM; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., Pereira M; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., da Silva Saraiva S; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., Annichino-Bizzacchi JM; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., de Moraes Mazetto B; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., Orsi FA; Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil. ferorsi@unicamp.br.; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas R. Tessália Vieira de Camargo, 126. Cidade Universitária, Campinas, SP, 13083-887, Brazil. ferorsi@unicamp.br.; Leiden University Medical Center (LUMC), Leiden, The Netherlands. ferorsi@unicamp.br.
المصدر: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2022 Feb; Vol. 53 (2), pp. 390-398. Date of Electronic Publication: 2021 Aug 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-742X (Electronic) Linking ISSN: 09295305 NLM ISO Abbreviation: J Thromb Thrombolysis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Dordrecht ; Norwell, MA] : Kluwer Academic Publishers, c1994-
مواضيع طبية MeSH: Antiphospholipid Syndrome* , Dyslipidemias*, Adult ; Cholesterol, HDL ; Diet ; Female ; Humans ; Lipids ; Prospective Studies
مستخلص: Although dyslipidemia is associated with poorer prognosis in antiphospholipid syndrome (APS), the management of lipid disorders can be challenging. While statins may increase the bleeding risk associated with anticoagulation, the effectiveness of hypolipid diet (HD) has not yet been established in patients with autoimmune disorders. In this study, we evaluated whether HD is associated with decreases in cholesterol levels in patients with thrombotic primary APS (t-PAPS) and dyslipidemia. Nutritional and lipid profiles were assessed before HD was initiated (baseline) and after 3 and 6 months with HD. A 24-h dietary recall was applied to assess the adherence to the diet. Forty-four patients were included, mean age was 43 years (± 12.93) and 65% were female. After HD was started, the intake of carbohydrates, lipids, saturated fats and cholesterol decreased, whereas dietary fiber intake increased. Levels of total cholesterol (TC) and non-high density lipoprotein cholesterol (non-HDL-C) decreased after 3 and 6 months of HD, as compared to baseline (P = 0.007 and P = 0.008). Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) values did not change during the study period. The mean body mass index (BMI) decreased from 28.4 to 27.8 kg/m 2 after six months of HD (p < 0.0001). In subgroup analysis, the effects of HD were more pronounced in patients with high TC, LDL-C or non-HDL-C levels at baseline and in those without obesity or hypertension. Nutritional intervention is feasible among t-PAPS and could be an alternative therapy to modulate lipid metabolism in this population.
(© 2021. The Author(s).)
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معلومات مُعتمدة: 2016/14172-6 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: Antiphospholipid syndrome; Atherosclerosis; Cardiovascular risk; Diet therapy; Dyslipidemia; Hypolipid diet
المشرفين على المادة: 0 (Cholesterol, HDL)
0 (Lipids)
تواريخ الأحداث: Date Created: 20210821 Date Completed: 20220406 Latest Revision: 20220406
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8904340
DOI: 10.1007/s11239-021-02542-z
PMID: 34417945
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-742X
DOI:10.1007/s11239-021-02542-z