دورية أكاديمية
The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus.
| العنوان: | The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus. |
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| المؤلفون: | Lensen KDF; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Escudero-Sanchez R; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain., Cobo J; Department of Infectious Diseases, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain., Trebše R; Service for Bone Infections, Valdoltra Orthopaedic Hospital, Ankaran, Slovenia., Gubavu C; Department of Infectious and Tropical Diseases, CHR Orléans, Orléans, France., Tedeschi S; Infectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna Policlinico di Sant Orsola, Bologna, Italy., Lomas JM; Department of Infectious Diseases, Virgen del Rocio University Hospital, Seville, Spain., Arvieux C; Department of Infectious Diseases and Intensive Care, Centre Hospitalier Universitaire de Rennes, Rennes, France., Rodriguez-Pardo D; Infectious Diseases Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain., Fantoni M; UOC Malattie Infettive, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Pais MJG; Infectious Diseases Unit, Hospital Universitario Lucus Augusti, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Lugo, Spain., Jover F; Unidad de Enfermedades Infecciosas, Hospital Universitario San Juan de Alicante, Alicante, Spain., Salles MJC; Unit of Infectious Diseases, Department of Internal Medicine, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil., Sancho I; Department of Infectious Diseases, Hospital Reina Sofía de Tudela, Navarra, Spain., Sampedro MF; Servicio de Enfermedades Infecciosas, Hospital Universitario Marqués de Valdecilla, Santander, Spain., Soriano A; Department of Infectious Diseases, Hospital Clínic, IDIBAPS, Catalonia, Barcelona, Spain., Wouthuyzen-Bakker M; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Escmid Study Group Of Implant Associated Infections Esgiai; A full list of authors appears at the end of the paper. |
| المصدر: | Journal of bone and joint infection [J Bone Jt Infect] 2021 Aug 17; Vol. 6 (7), pp. 313-319. Date of Electronic Publication: 2021 Aug 17 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Copernicus Publications Country of Publication: Germany NLM ID: 101701849 Publication Model: eCollection Cited Medium: Print ISSN: 2206-3552 (Print) Linking ISSN: 22063552 NLM ISO Abbreviation: J Bone Jt Infect Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Göttingen] : Copernicus Publications Original Publication: Sydney : Ivyspring International Publisher, [2016]- |
| مستخلص: | Objectives : Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a draining sinus has never been investigated. Methods : A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of > 6 months of oral antibiotic therapy. Results : SAT was initiated in 63 of 72 (87.5 %) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4 % vs. 88.9 %; p = 0 .68). In total, 27 % of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42 %, 6.3 %, and 3.2 % of cases, respectively. However, the sinus tract tended to close more often (42 % vs. 13 %; p = 0 .14), and a higher resolution of pain was observed (35 % vs. 14 %; p = 0 .22) in patients receiving SAT. Conclusions : SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed. Competing Interests: Rihard Trebse is associate editor of . Alex Soriano Viladomiu is associate editor of . Marjan Wouthuyzen-Bakker is associate editor of . (Copyright: © 2021 Karel-Jan Dag François Lensen et al.) |
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| تواريخ الأحداث: | Date Created: 20210823 Latest Revision: 20240814 |
| رمز التحديث: | 20240814 |
| مُعرف محوري في PubMed: | PMC8375509 |
| DOI: | 10.5194/jbji-6-313-2021 |
| PMID: | 34422548 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2206-3552 |
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| DOI: | 10.5194/jbji-6-313-2021 |