دورية أكاديمية
Variation in plasma concentration of insulin-like growth factor-1 and its covariation with liveweight in mice.
| العنوان: | Variation in plasma concentration of insulin-like growth factor-1 and its covariation with liveweight in mice. |
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| المؤلفون: | Blair HT; Department of Animal Science, Massey University, Palmerston North, New Zealand., McCutcheon SN, Mackenzie DD, Gluckman PD, Ormsby JE |
| المصدر: | Australian journal of biological sciences [Aust J Biol Sci] 1987; Vol. 40 (3), pp. 287-93. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Commonwealth Scientific And Industrial Research Organization Country of Publication: Australia NLM ID: 0370613 Publication Model: Print Cited Medium: Print ISSN: 0004-9417 (Print) Linking ISSN: 00049417 NLM ISO Abbreviation: Aust J Biol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: East Melbourne : Commonwealth Scientific And Industrial Research Organization Original Publication: East Melbourne. |
| مواضيع طبية MeSH: | Body Weight*, Insulin-Like Growth Factor I/*blood , Somatomedins/*blood, Aging/blood ; Animals ; Insulin-Like Growth Factor I/genetics ; Mice ; Mice, Inbred Strains ; Phenotype ; Sex Characteristics |
| مستخلص: | Three experiments were undertaken to examine the degree and causes of variation in plasma concentrations of insulin-like growth factor-1 (IGF-1) in mice. The relationship between IGF-1 concentrations and liveweight was also examined. In all three experiments, a number of non-genetic factors were found to contribute significantly to the variation in IGF-1 concentrations, the most important of these being sex and litter size. In one experiment, where pups from 16 litters were cross-fostered to avoid the confounding of maternal and direct genetic effects, a heritability of 0.40 +/- 0.27 was estimated for plasma IGF-1 concentration at 35 days of age. To examine further the existence of genetic variation in plasma concentrations of IGF-1 and the genetic covariation between plasma IGF-1 levels and other body traits, a selection experiment with mice has been initiated. Moderate to strong phenotypic correlations between IGF-1 concentrations and weight at an early age have been found in all three experiments. |
| المشرفين على المادة: | 0 (Somatomedins) 67763-96-6 (Insulin-Like Growth Factor I) |
| تواريخ الأحداث: | Date Created: 19870101 Date Completed: 19880418 Latest Revision: 20191022 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1071/bi9870287 |
| PMID: | 3442513 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0004-9417 |
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| DOI: | 10.1071/bi9870287 |