دورية أكاديمية
Clinical prediction rules for the diagnosis of neuritis in leprosy.
| العنوان: | Clinical prediction rules for the diagnosis of neuritis in leprosy. |
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| المؤلفون: | Giesel LM; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil. louisegiesel@gmail.com.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. louisegiesel@gmail.com., Hökerberg YHM; Laboratory of Clinical Epidemiology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz, Brazil.; School of Medicine, Estácio de Sá University, Rio de Janeiro, Brazil., Pitta IJR; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Andrade LR; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Moraes DB; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., da Costa Nery JA; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil., Sarno EN; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil., Jardim MR; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, 21240-360, Brazil.; Post-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil. |
| المصدر: | BMC infectious diseases [BMC Infect Dis] 2021 Aug 23; Vol. 21 (1), pp. 858. Date of Electronic Publication: 2021 Aug 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Leprosy*/complications , Leprosy*/diagnosis , Neuralgia* , Neuritis*/diagnosis, Brazil ; Clinical Decision Rules ; Cross-Sectional Studies ; Humans |
| مستخلص: | Background: Diagnosing neuritis in leprosy patients with neuropathic pain or chronic neuropathy remains challenging since no specific laboratory or neurophysiological marker is available. Methods: In a cross-sectional study developed at a leprosy outpatient clinic in Rio de Janeiro, RJ, Brazil, 54 individuals complaining of neural pain (single or multiple sites) were classified into two groups ("neuropathic pain" or "neuritis") by a neurological specialist in leprosy based on anamnesis together with clinical and electrophysiological examinations. A neurologist, blind to the pain diagnoses, interviewed and examined the participants using a standardized form that included clinical predictors, pain features, and neurological symptoms. The association between the clinical predictors and pain classifications was evaluated via the Pearson Chi-Square or Fisher's exact test (p < 0.05). Results: Six clinical algorithms were generated to evaluate sensitivity and specificity, with 95% confidence intervals, for clinical predictors statistically associated with neuritis. The most conclusive clinical algorithm was: pain onset at any time during the previous 90 days, or in association with the initiation of neurological symptoms during the prior 30-day period, necessarily associated with the worsening of pain upon movement and nerve palpation, with 94% of specificity and 35% of sensitivity. Conclusion: This algorithm could help physicians confirm neuritis in leprosy patients with neural pain, particularly in primary health care units with no access to neurologists or electrophysiological tests. (© 2021. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Clinical prediction rules; Leprosy; Neuritis; Neuropathic pain; Sensitivity; Specificity |
| تواريخ الأحداث: | Date Created: 20210824 Date Completed: 20210924 Latest Revision: 20210924 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8381570 |
| DOI: | 10.1186/s12879-021-06545-2 |
| PMID: | 34425777 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2334 |
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| DOI: | 10.1186/s12879-021-06545-2 |