دورية أكاديمية
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Emergence of Caenorhabditis elegans as a Model Organism for Dissecting the Gut-Brain Axis.

التفاصيل البيبلوغرافية
العنوان: Emergence of Caenorhabditis elegans as a Model Organism for Dissecting the Gut-Brain Axis.
المؤلفون: Ortiz de Ora L; Department of Chemistry, University of California, Irvine, California, USA., Bess EN; Department of Chemistry, University of California, Irvine, California, USA.; Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA.
المصدر: MSystems [mSystems] 2021 Aug 31; Vol. 6 (4), pp. e0075521. Date of Electronic Publication: 2021 Aug 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101680636 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2379-5077 (Print) Linking ISSN: 23795077 NLM ISO Abbreviation: mSystems Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Society for Microbiology, [2016]-
مستخلص: Accumulating evidence links the gut microbiome to neuronal functions in the brain. Given the increasing prevalence of brain disorders, there is a critical need to understand how gut microbes impact neuronal functions so that targeted therapeutic interventions can be developed. In this commentary, we discuss what makes the nematode Caenorhabditis elegans a valuable model for dissecting the molecular basis of gut microbiome-brain interactions. With a fully mapped neuronal circuitry, C. elegans is an effective model for studying signaling of the nervous system in a context that bears translational relevance to human disease. We highlight C. elegans as a potent but underexploited tool to interrogate the influence of the bacterial variable on the complex equation of the nervous system. We envision that routine use of gnotobiotic C. elegans to examine the gut-brain axis will be an enabling technology for the development of novel therapeutic interventions for brain diseases.
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معلومات مُعتمدة: UC | University of California, Irvine (UCI)
فهرسة مساهمة: Keywords: C. elegans; gnotobiotics; gut microbiome; gut–brain axis; neurodegenerative diseases; neurosignals
تواريخ الأحداث: Date Created: 20210824 Latest Revision: 20211215
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8407351
DOI: 10.1128/mSystems.00755-21
PMID: 34427498
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-5077
DOI:10.1128/mSystems.00755-21