دورية أكاديمية
Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection.
| العنوان: | Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection. |
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| المؤلفون: | Arcanjo A; Medical Biochemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Guimarães Pinto K; Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Logullo J; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Leite PEC; Directory of Metrology Applied to Life Sciences - DIMAV, National Institute of Metrology Quality and Technology - INMETRO, Duque de Caxias, Rio de Janeiro, Brazil., Menezes CCB; Tuberculosis Research Laboratory, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Freire-de-Lima L; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Diniz-Lima I; Veterinary Institute, Federal Rural University of Rio de Janeiro, Rio de Janeiro, Brazil., Decoté-Ricardo D; Veterinary Institute, Federal Rural University of Rio de Janeiro, Rio de Janeiro, Brazil., Nunes Rodrigues-da-Silva R; Laboratory of Monoclonal Antibody Technology, Biomanguinhos, Fiocruz, Rio de Janeiro, Brazil., Geraldo Freire-de-Lima C; Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Almeida Filardy A; Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Lima-Junior JDC; Immunoparasitology Laboratory, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil., Luiz Bertho A; Immunoparasitology Laboratory, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil., De Luca PM; Immunoparasitology Laboratory, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil., Mauro Granjeiro J; Directory of Metrology Applied to Life Sciences - DIMAV, National Institute of Metrology Quality and Technology - INMETRO, Duque de Caxias, Rio de Janeiro, Brazil.; Dental School, Fluminense Federal University - UFF, Niteroi, Rio de Janeiro, Brazil., Coutinho Barroso SP; Molecular Biology Laboratory, Institute of Biomedical Research, Marcílio Dias Naval Hospital, Navy of Brazil, Rio de Janeiro, Brazil., Conceição-Silva F; Immunoparasitology Laboratory, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil., Savino W; Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation - INCT-NIM, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; Rio de Janeiro Research Network on Neuroinflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Morrot A; Tuberculosis Research Laboratory, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Immunoparasitology Laboratory, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil.; Rio de Janeiro Research Network on Neuroinflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2021 Nov 22; Vol. 224 (10), pp. 1672-1683. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | COVID-19*, CD28 Antigens ; Critical Illness ; Cytokines/metabolism ; Humans ; SARS-CoV-2 |
| مستخلص: | Background: Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm. Methods: In this study, we report that severe acutely infected patients have high levels of both type-1 and type-2 cytokines. Results: Our results show abnormal cytokine levels upon T-cell stimulation, in a nonpolarized profile. Furthermore, our findings indicate that this hyperactive cytokine response is associated with a significantly increased frequency of late-differentiated T cells with particular phenotype of effector exhausted/senescent CD28-CD57+ cells. Of note, we demonstrated for the first time an increased frequency of CD3+CD4+CD28-CD57+ T cells with expression of programmed death 1, one of the hallmarks of T-cell exhaustion. Conclusions: These findings reveal that COVID-19 is associated with acute immunodeficiency, especially within the CD4+ T-cell compartment, and points to possible mechanisms of loss of clonal repertoire and susceptibility to viral relapse and reinfection events. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; exhausted/senescent T cells; immunopathology |
| المشرفين على المادة: | 0 (CD28 Antigens) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20210824 Date Completed: 20220930 Latest Revision: 20221204 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8513399 |
| DOI: | 10.1093/infdis/jiab425 |
| PMID: | 34427670 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiab425 |