دورية أكاديمية
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.
| العنوان: | Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans. |
|---|---|
| المؤلفون: | Kanen JW; Department of Psychology, University of Cambridge, Cambridge, UK. jonathan.kanen@gmail.com.; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. jonathan.kanen@gmail.com., Apergis-Schoute AM; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Department of Neuroscience, Psychology, and Behaviour, University of Leicester, Leicester, UK., Yellowlees R; Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Arntz FE; Department of Psychology, Leiden University, Leiden, The Netherlands., van der Flier FE; Department of Experimental Psychology and Helmholtz Institute, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands., Price A; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK., Cardinal RN; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK., Christmas DM; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK., Clark L; Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Sahakian BJ; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK., Crockett MJ; Department of Psychology, Yale University, New Haven, CT, USA., Robbins TW; Department of Psychology, University of Cambridge, Cambridge, UK.; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. |
| المصدر: | Molecular psychiatry [Mol Psychiatry] 2021 Dec; Vol. 26 (12), pp. 7200-7210. Date of Electronic Publication: 2021 Aug 24. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996- |
| مواضيع طبية MeSH: | Reversal Learning*/physiology , Serotonin*, Conditioning, Operant ; Humans ; Punishment ; Reward |
| مستخلص: | Serotonin is involved in updating responses to changing environmental circumstances. Optimising behaviour to maximise reward and minimise punishment may require shifting strategies upon encountering new situations. Likewise, autonomic responses to threats are critical for survival yet must be modified as danger shifts from one source to another. Whilst numerous psychiatric disorders are characterised by behavioural and autonomic inflexibility, few studies have examined the contribution of serotonin in humans. We modelled both processes, respectively, in two independent experiments (N = 97). Experiment 1 assessed instrumental (stimulus-response-outcome) reversal learning whereby individuals learned through trial and error which action was most optimal for obtaining reward or avoiding punishment initially, and the contingencies subsequently reversed serially. Experiment 2 examined Pavlovian (stimulus-outcome) reversal learning assessed by the skin conductance response: one innately threatening stimulus predicted receipt of an uncomfortable electric shock and another did not; these contingencies swapped in a reversal phase. Upon depleting the serotonin precursor tryptophan-in a double-blind randomised placebo-controlled design-healthy volunteers showed impairments in updating both actions and autonomic responses to reflect changing contingencies. Reversal deficits in each domain, furthermore, were correlated with the extent of tryptophan depletion. Initial Pavlovian conditioning, moreover, which involved innately threatening stimuli, was potentiated by depletion. These results translate findings in experimental animals to humans and have implications for the neurochemical basis of cognitive inflexibility. (© 2021. The Author(s).) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; MC_PC_17213 United Kingdom MRC_ Medical Research Council; 104631/Z/14/Z United Kingdom WT_ Wellcome Trust; United Kingdom DH_ Department of Health |
| المشرفين على المادة: | 333DO1RDJY (Serotonin) |
| تواريخ الأحداث: | Date Created: 20210825 Date Completed: 20220314 Latest Revision: 20230206 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8873011 |
| DOI: | 10.1038/s41380-021-01240-9 |
| PMID: | 34429517 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41380-021-01240-9 |