دورية أكاديمية
أعرض في EDS

Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer.

التفاصيل البيبلوغرافية
العنوان: Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer.
المؤلفون: Sabido EM; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines., Tenebro CP; Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines., Trono DJVL; Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines., Vicera CVB; Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines., Leonida SFL; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines., Maybay JJWB; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines., Reyes-Salarda R; Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines.; Department of Biology, College of Liberal Arts, Sciences, and Education, University of San Agustin, Iloilo City 5000, Philippines., Amago DS; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines., Aguadera AMV; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines., Octaviano MC; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines., Saludes JP; Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines.; Department of Chemistry, College of Liberal Arts, Sciences, and Education, University of San Agustin, Iloilo City 5000, Philippines.; Tuklas Lunas Development Center, University of San Agustin, Iloilo City 5000, Philippines.; Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development (PCHRD), Bicutan, Taguig City 1631, Philippines., Dalisay DS; Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines.; Department of Biology, College of Liberal Arts, Sciences, and Education, University of San Agustin, Iloilo City 5000, Philippines.; Tuklas Lunas Development Center, University of San Agustin, Iloilo City 5000, Philippines.; Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development (PCHRD), Bicutan, Taguig City 1631, Philippines.
المصدر: Marine drugs [Mar Drugs] 2021 Jul 31; Vol. 19 (8). Date of Electronic Publication: 2021 Jul 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Geologic Sediments*, Anti-Bacterial Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Plant Extracts/*pharmacology , Streptomyces/*chemistry, Aquatic Organisms ; Cell Line, Tumor/drug effects ; Female ; Gram-Positive Bacteria/drug effects ; Humans ; Microbial Sensitivity Tests ; Oceans and Seas ; Ovarian Neoplasms/drug therapy ; Philippines ; Phytotherapy ; RNA, Ribosomal, 16S/genetics ; Streptomyces/genetics
مستخلص: Marine sediments host diverse actinomycetes that serve as a source of new natural products to combat infectious diseases and cancer. Here, we report the biodiversity, bioactivities against ESKAPE pathogens ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter spp.) and ovarian cancer, and metabolites variation among culturable actinomycetes isolated from the marine sediments of Visayan Sea, Philippines. We identified 15 Streptomyces species based on a 16S rRNA gene sequence analysis. The crude extracts of 10 Streptomyces species have inhibited the growth of ESKAPE pathogens with minimum inhibitory concentration (MIC) values ranging from 0.312 mg/mL to 20 mg/mL depending on the strain and pathogens targeted. Additionally, ten crude extracts have antiproliferative activity against A2780 human ovarian carcinoma at 2 mg/mL. To highlight, we observed that four phylogenetically identical Streptomyces albogriseolus strains demonstrated variation in antibiotic and anticancer activities. These strains harbored type I and II polyketide synthase (PKS) and non-ribosomal synthetase (NRPS) genes in their genomes, implying that their bioactivity is independent of the polymerase chain reaction (PCR)-detected bio-synthetic gene clusters (BGCs) in this study. Metabolite profiling revealed that the taxonomically identical strains produced core and strain-specific metabolites. Thus, the chemical diversity among these strains influences the variation observed in their biological activities. This study expanded our knowledge on the potential of marine-derived Streptomyces residing from the unexplored regions of the Visayan Sea as a source of small molecules against ESKAPE pathogens and cancer. It also highlights that Streptomyces species strains produce unique strain-specific secondary metabolites; thus, offering new chemical space for natural product discovery.
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معلومات مُعتمدة: PCHRD Tuklas Lunas Development Center Program Department of Science and Technology, Philippines
فهرسة مساهمة: Keywords: ESKAPE pathogens; antibiotics; chemodiversity; marine Streptomyces strains; marine sediments; metabolomics; nonribosomal peptide synthetase; polyketide synthase
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Antineoplastic Agents)
0 (Plant Extracts)
0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20210826 Date Completed: 20220111 Latest Revision: 20220111
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8399204
DOI: 10.3390/md19080441
PMID: 34436280
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md19080441