دورية أكاديمية
أعرض في EDS

A Biochemical and Pharmacological Characterization of Phospholipase A 2 and Metalloproteinase Fractions from Eastern Russell's Viper ( Daboia siamensis ) Venom: Two Major Components Associated with Acute Kidney Injury.

التفاصيل البيبلوغرافية
العنوان: A Biochemical and Pharmacological Characterization of Phospholipase A 2 and Metalloproteinase Fractions from Eastern Russell's Viper ( Daboia siamensis ) Venom: Two Major Components Associated with Acute Kidney Injury.
المؤلفون: Chaisakul J; Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand., Khow O; Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand., Wiwatwarayos K; Institute of Pathology, Ministry of Public Health, Bangkok 10400, Thailand., Rusmili MRA; Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Malaysia., Prasert W; Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand., Othman I; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 46150, Malaysia., Abidin SAZ; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 46150, Malaysia., Charoenpitakchai M; Department of Pathology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand., Hodgson WC; Monash Venom Group, Department of Pharmacology, Biomedical Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Chanhome L; Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand., Chaiyabutr N; Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand.
المصدر: Toxins [Toxins (Basel)] 2021 Jul 26; Vol. 13 (8). Date of Electronic Publication: 2021 Jul 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Daboia*, Metalloproteases/*toxicity , Phospholipases A2/*toxicity , Reptilian Proteins/*toxicity , Viper Venoms/*toxicity, Acute Kidney Injury/pathology ; Animals ; Chickens ; Kidney/pathology ; Male ; Metalloproteases/isolation & purification ; Mice, Inbred ICR ; Muscle, Skeletal/physiology ; Myocardium/pathology ; Phospholipases A2/chemistry ; Phospholipases A2/isolation & purification ; Reptilian Proteins/isolation & purification ; Spleen/pathology ; Viper Venoms/chemistry ; Mice
مستخلص: Acute kidney injury (AKI) following Eastern Russell's viper ( Daboia siamensis ) envenoming is a significant symptom in systemically envenomed victims. A number of venom components have been identified as causing the nephrotoxicity which leads to AKI. However, the precise mechanism of nephrotoxicity caused by these toxins is still unclear. In the present study, we purified two proteins from D. siamensis venom, namely RvPLA 2 and RvMP. Protein identification using LCMS/MS confirmed the identity of RvPLA 2 to be snake venom phospholipase A 2 (SVPLA 2 ) from Thai D. siamensis venom, whereas RvMP exhibited the presence of a factor X activator with two subunits. In vitro and in vivo pharmacological studies demonstrated myotoxicity and histopathological changes of kidney, heart, and spleen. RvPLA 2 (3-10 µg/mL) caused inhibition of direct twitches of the chick biventer cervicis muscle preparation. After administration of RvPLA 2 or RvMP (300 µg/kg, i.p.) for 24 h, diffuse glomerular congestion and tubular injury with minor loss of brush border were detected in envenomed mice. RvPLA 2 and RvMP (300 µg/kg; i.p.) also induced congestion and tissue inflammation of heart muscle as well as diffuse congestion of mouse spleen. This study showed the significant roles of PLA 2 and SVMP in snake bite envenoming caused by Thai D. siamensis and their similarities with observed clinical manifestations in envenomed victims. This study also indicated that there is a need to reevaluate the current treatment strategies for Thai D. siamensis envenoming, given the potential for irreversible nephrotoxicity.
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فهرسة مساهمة: Keywords: Russell’s viper; kidney; myotoxicity; nephrotoxicity; phospholipase A2; venom
المشرفين على المادة: 0 (Reptilian Proteins)
0 (Viper Venoms)
EC 3.1.1.4 (Phospholipases A2)
EC 3.4.- (Metalloproteases)
تواريخ الأحداث: Date Created: 20210826 Date Completed: 20220127 Latest Revision: 20240226
رمز التحديث: 20240226
مُعرف محوري في PubMed: PMC8402394
DOI: 10.3390/toxins13080521
PMID: 34437392
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins13080521