دورية أكاديمية
Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice.
| العنوان: | Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. |
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| المؤلفون: | Almeida CAF; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil., Pereira-Junior AA; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil., Rangel JG; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil., Pereira BP; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil., Costa KCM; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil., Bruno V; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo, SP, Brazil., Silveira GO; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo, SP, Brazil., Ceron CS; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil., Yonamine M; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo, SP, Brazil., Camarini R; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1524, Prédio 1, 05508-900, São Paulo, SP, Brazil., Garcia RCT; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, 1° Andar, 09913-030, Diadema, SP, Brazil., Marcourakis T; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo, SP, Brazil., Torres LH; Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil. Electronic address: larissa.torres@unifal-mg.edu.br. |
| المصدر: | Behavioural brain research [Behav Brain Res] 2022 Jan 07; Vol. 416, pp. 113546. Date of Electronic Publication: 2021 Aug 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8004872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7549 (Electronic) Linking ISSN: 01664328 NLM ISO Abbreviation: Behav Brain Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Beverages*, Banisteriopsis/*drug effects , Behavior, Animal/*drug effects , Ethanol/*pharmacology , Hallucinogens/*pharmacology , Neuronal Plasticity/*drug effects, Animals ; Hallucinogens/administration & dosage ; Male ; Mice |
| مستخلص: | Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral sensitization (EIBS). Swiss mice received 2.2 g/kg ethanol or saline IP injections every other day across nine days (D1, D3, D5, D7, and D9), and locomotor activity was evaluated 10 min after each injection. Then, animals were treated daily with ayahuasca (corresponding to 1.76 mg/kg of N,N-dimethyltryptamine, DMT) or water by oral gavage for eight consecutive days. On the seventh day, mice were evaluated in the elevated plus maze. Then, mice were challenged with a single dose of ethanol to measure their locomotor activity. Dopamine receptors, serotonin receptors, dynorphin, and prodynorphin levels were quantified in the striatum and hippocampus by blot analysis. Repeated ethanol administration resulted in EIBS. However, those animals treated with ayahuasca had an attenuated EIBS. Moreover, ayahuasca reduced the anxiogenic response to ethanol withdrawal and prevented the ethanol-induced changes on 5-HT1a receptor and prodynorphin levels in the hippocampus and reduced ethanol effects in the dynorphin/prodynorphin ratio levels in the striatum. These results suggest a potential application of ayahuasca to modulate the neuroplastic changes induced by ethanol. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Ayahuasca; Behavioral sensitization; Ethanol; N,N-dimethyltryptamine; Withdrawal; β-carboline |
| المشرفين على المادة: | 0 (Hallucinogens) 3K9958V90M (Ethanol) |
| تواريخ الأحداث: | Date Created: 20210826 Date Completed: 20220317 Latest Revision: 20220317 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.bbr.2021.113546 |
| PMID: | 34437939 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7549 |
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| DOI: | 10.1016/j.bbr.2021.113546 |