دورية أكاديمية
أعرض في EDS

Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary?

التفاصيل البيبلوغرافية
العنوان: Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary?
المؤلفون: Ferrari R; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., Boracchi P; Dipartimento di Scienze Cliniche e di Comunità, Laboratorio di Statistica Medica, Biometria ed Eopidemiologia 'G.A. Maccacaro', Università degli Studi di Milano, 20122 Milano, Italy., Chiti LE; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., Manfredi M; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., Giudice C; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., De Zani D; Centro Clinico-Veterinario e Zootecnico-Sperimentale, Veterinary Teaching Hospital, Università degli Studi di Milano, 26900 Lodi, Italy., Spediacci C; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., Recordati C; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., Grieco V; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy., Gariboldi EM; Centro Clinico-Veterinario e Zootecnico-Sperimentale, Veterinary Teaching Hospital, Università degli Studi di Milano, 26900 Lodi, Italy., Stefanello D; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy.
المصدر: Animals : an open access journal from MDPI [Animals (Basel)] 2021 Aug 11; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Molecular Diversity Preservation International Country of Publication: Switzerland NLM ID: 101635614 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2615 (Print) Linking ISSN: 20762615 NLM ISO Abbreviation: Animals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2011-
مستخلص: The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. The study aimed to assess the association between clinicopathological variables and SLN status, determining the identification of dogs at lower risk of SLN metastases. Dogs with integumentary MCT were admitted to the lymphoscintigraphic mapping and subsequent biopsy of SLN. The association between clinicopathological variables of MCT and SLN status was statistically tested, both considering occult and overt metastasis together (HN2-HN3) and overt metastasis (HN3) alone. Fifty low-grade cutaneous MCT and 16 subcutaneous MCT were included. A small to moderate association between integumentary MCT ≥ 3 cm and HN2-HN3 SLN was found. A strong association of integumentary MCT dimension and subcutaneous MCT with HN3 SLN occurred. Dimension of low-grade cutaneous and subcutaneous MCT seems to correlate with SLN status, but additional study should confirm this data before excluding small MCT to the SLN biopsy. On the contrary, the study results induce a solid suggestion for mapping and biopsy of the SLN in MCT > 3 cm and subcutaneous MCT.
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فهرسة مساهمة: Keywords: lymphoscintigraphy; mast cell tumor; metastasis; sentinel lymph node; staging
تواريخ الأحداث: Date Created: 20210827 Latest Revision: 20210830
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8388797
DOI: 10.3390/ani11082373
PMID: 34438830
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2615
DOI:10.3390/ani11082373