دورية أكاديمية
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Design of Liposomes Carrying HelixComplex Snail Mucus: Preliminary Studies.

التفاصيل البيبلوغرافية
العنوان: Design of Liposomes Carrying HelixComplex Snail Mucus: Preliminary Studies.
المؤلفون: Alogna A; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy., Gentili V; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy., Trapella C; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 70 Eliporto Street, I-44121 Ferrara, Italy., Hallan SS; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biotechnology Interuniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, I-44121 Ferrara, Italy., Sguizzato M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biotechnology Interuniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, I-44121 Ferrara, Italy., Strazzabosco G; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy., Fernández M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy., Cortesi R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biotechnology Interuniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, I-44121 Ferrara, Italy., Rizzo R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 70 Eliporto Street, I-44121 Ferrara, Italy., Bortolotti D; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 04; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Mucus/*chemistry , Snails/*chemistry, Animals ; Cell Death ; Cell Line ; Fibroblasts/cytology ; Freeze Fracturing ; Humans ; Lipids/analysis ; Liposomes/ultrastructure ; Spectrophotometry, Infrared ; Wound Healing/drug effects
مستخلص: In recent decades liposomes have been used in different field thanks to their ability to act as a vehicle for a wide range of biomolecules, their great versatility and their easy production. The aim of this study was to evaluate liposomes as a vehicle for the actives present in the HelixComplex (HC) snail mucus for topical delivery. Liposomes composed of a mixture of phosphatidylcholine, cholesterol and octadecylamine were prepared with and without HC (empty liposomes) and their biological efficacy was tested by evaluating cell viability and migration. HC-loaded liposomes (LHC) were stable throughout 60 days of observation, and showed interesting effects on wound healing reconstitution. In particular, we observed that 25 µg/mL LHC were already able to induce a higher cell monolayer reconstitution in comparison to the untreated samples and HC treated samples after only 4 h (28% versus 10% and 7%, p = 0.03 and p = 0.003, respectively). The effect was more evident at 24 h in comparison with the untreated control (54% versus 21.2% and 41.6%, p = 0.006 and p = NS, respectively). These results represent a preliminary, but promising, novelty in the delivery strategy of the actives present in the HelixComplex mucus.
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معلومات مُعتمدة: ARS01_01163 PON "Research and Innovation" 2014-2020; FAR2020 University of Ferrara; FAR2019 University of Ferrara; CCIAA2018 Chamber of Commerce of Ferrara; CCIAA2019 Chamber of Commerce of Ferrara
فهرسة مساهمة: Keywords: HelixComplex; MTT test; drug delivery; liposomes; slime mucus
المشرفين على المادة: 0 (Lipids)
0 (Liposomes)
تواريخ الأحداث: Date Created: 20210827 Date Completed: 20210916 Latest Revision: 20210916
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8399803
DOI: 10.3390/molecules26164709
PMID: 34443296
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26164709