دورية أكاديمية
Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate.
العنوان: | Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate. |
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المؤلفون: | Rosario FJ; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Kramer A; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Li C; Texas Pregnancy and Life-Course Health Center, Department of Animal Sciences, University of Wyoming, Laramie, WY 82071, USA.; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Galan HL; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Powell TL; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Nathanielsz PW; Texas Pregnancy and Life-Course Health Center, Department of Animal Sciences, University of Wyoming, Laramie, WY 82071, USA.; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA., Jansson T; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. |
المصدر: | Nutrients [Nutrients] 2021 Aug 23; Vol. 13 (8). Date of Electronic Publication: 2021 Aug 23. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI Publishing |
مواضيع طبية MeSH: | Diet, Protein-Restricted* , Maternal-Fetal Exchange*, Amino Acid Transport System A/*metabolism , Amino Acid Transport System L/*metabolism , Amino Acids/*metabolism , Fetal Growth Retardation/*etiology , Placenta/*metabolism, Animals ; Biological Transport ; Disease Models, Animal ; Female ; Fetal Development ; Fetal Growth Retardation/metabolism ; Fetal Growth Retardation/physiopathology ; Gestational Age ; Maternal Nutritional Physiological Phenomena ; Papio ; Pregnancy |
مستخلص: | Intrauterine growth restriction (IUGR) is associated with reduced placental amino acid transport (AAT). However, it remains to be established if changes in AAT contribute to restricted fetal growth. We hypothesized that reduced in vivo placental AAT precedes the development of IUGR in baboons with maternal nutrient restriction (MNR). Baboons were fed either a control (ad libitum) or MNR diet (70% of control diet) from gestational day (GD) 30. At GD 140, in vivo transplacental AA transport was measured by infusing nine (13) C- or (2) H-labeled essential amino acids (EAAs) as a bolus into the maternal circulation at cesarean section. A fetal vein-to-maternal artery mole percent excess ratio for each EAA was measured. Microvillous plasma membrane (MVM) system A and system L transport activity were determined. Fetal and placental weights were not significantly different between MNR and control. In vivo, the fetal vein-to-maternal artery mole percent excess ratio was significantly decreased for tryptophan in MNR. MVM system A and system L activity was markedly reduced in MNR. Reduction of in vivo placental amino acid transport precedes fetal growth restriction in the non-human primate, suggesting that reduced placental amino acid transfer may contribute to IUGR. |
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معلومات مُعتمدة: | P51 OD011133 United States OD NIH HHS; P01-HD-21350 National Institute of Child Health and Human Development |
فهرسة مساهمة: | Keywords: amino acids; fetal growth restriction; maternal-fetal exchange; neutral; trophoblast |
المشرفين على المادة: | 0 (Amino Acid Transport System A) 0 (Amino Acid Transport System L) 0 (Amino Acids) |
تواريخ الأحداث: | Date Created: 20210827 Date Completed: 20210922 Latest Revision: 20220310 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8401823 |
DOI: | 10.3390/nu13082892 |
PMID: | 34445051 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6643 |
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DOI: | 10.3390/nu13082892 |