دورية أكاديمية
أعرض في EDS

Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury.

التفاصيل البيبلوغرافية
العنوان: Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury.
المؤلفون: Abcouwer SF; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA. sabcouwe@umich.edu., Shanmugam S; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA., Muthusamy A; Esperovax Inc., Plymouth, MI, 48170, USA., Lin CM; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA., Kong D; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA., Hager H; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA., Liu X; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA., Antonetti DA; Department of Ophthalmology and Visual Sciences, Michigan Medicine, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, 48105, USA.; Department of Molecular and Integrative Physiology, Ann Arbor, MI, 48109, USA.
المصدر: Journal of neuroinflammation [J Neuroinflammation] 2021 Aug 26; Vol. 18 (1), pp. 186. Date of Electronic Publication: 2021 Aug 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2004-
مواضيع طبية MeSH: Blood-Retinal Barrier/*pathology , Inflammation/*pathology , Reperfusion Injury/*pathology , Retina/*pathology , Retinal Vessels/*pathology, Animals ; Apoptosis/physiology ; Capillary Permeability/physiology ; DNA Fragmentation ; Disease Models, Animal ; Mice ; Microglia/metabolism ; Recovery of Function/physiology
مستخلص: Background: Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammation may also promote iBRB restoration.
Methods: Using the mouse retinal ischemia-reperfusion (IR) injury model, we followed the time course of neurodegeneration, inflammation, and iBRB disruption and repair to examine the relationship between resolution of inflammation and iBRB restoration and to determine if minocycline, a tetracycline derivative shown to reverse microglial activation, can hasten these processes.
Results: A 90-min ischemic insult followed by reperfusion in the retina induced cell apoptosis and inner retina thinning that progressed for approximately 2 weeks. IR increased vascular permeability within hours, which resolved between 3 and 4 weeks after injury. Increased vascular permeability coincided with alteration and loss of endothelial cell tight junction (TJ) protein content and disorganization of TJ protein complexes. Shunting of blood flow away from leaky vessels and dropout of leaky capillaries were eliminated as possible mechanisms for restoring the iBRB. Repletion of TJ protein contents occurred within 2 days after injury, long before restoration of the iBRB. In contrast, the eventual re-organization of TJ complexes at the cell border coincided with restoration of the barrier. A robust inflammatory response was evident a 1 day after IR and progressed to resolution over the 4-week time course. The inflammatory response included a rapid and transient infiltration of granulocytes and Ly6C + classical inflammatory monocytes, a slow accumulation of Ly6C neg monocyte/macrophages, and activation, proliferation, and mobilization of resident microglia. Extravasation of the majority of CD45 + leukocytes occurred from the superficial plexus. The presence of monocyte/macrophages and increased numbers of microglia were sustained until the iBRB was eventually restored. Intervention with minocycline to reverse microglial activation at 1 week after injury promoted early restoration of the iBRB coinciding with decreased expression of mRNAs for the microglial M1 markers TNF-α, IL-1β, and Ptgs2 (Cox-2) and increased expression of secreted serine protease inhibitor Serpina3n mRNA.
Conclusions: These results suggest that iBRB restoration occurs as TJ complexes are reorganized and that resolution of inflammation and restoration of the iBRB following retinal IR injury are functionally linked.
(© 2021. The Author(s).)
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معلومات مُعتمدة: P30EY007003 United States EY NEI NIH HHS; R01 EY012021 United States EY NEI NIH HHS; R01EY029349 United States EY NEI NIH HHS; P30DK020572 United States DK NIDDK NIH HHS; None Research to Prevent Blindness; P30 DK020572 United States DK NIDDK NIH HHS; P30 EY007003 United States EY NEI NIH HHS; R01 HL055374 United States HL NHLBI NIH HHS; R01 EY029349 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: Blood-retina barrier; Cox-2; Granulocytes; IL-1β; Ischemia-reperfusion injury; Leukocytes; Microglia; Minocycline; Monocytes; Myeloid-derived macrophages; Resolution of inflammation; Retinal vasculature; Serpina3n; TNF-α; Tight junctions
تواريخ الأحداث: Date Created: 20210827 Date Completed: 20220124 Latest Revision: 20220401
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8394696
DOI: 10.1186/s12974-021-02237-5
PMID: 34446062
قاعدة البيانات: MEDLINE
الوصف
تدمد:1742-2094
DOI:10.1186/s12974-021-02237-5