دورية أكاديمية
أعرض في EDS

PASCAL-based mitral valve repair in an all-comer population: acute and mid-term clinical results.

التفاصيل البيبلوغرافية
العنوان: PASCAL-based mitral valve repair in an all-comer population: acute and mid-term clinical results.
المؤلفون: Schlegel P; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; DZHK [German Centre for Cardiovascular Research], Partner site Heidelberg/Mannheim, Heidelberg, Germany., Crespo López P; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany., Kreusser MM; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; DZHK [German Centre for Cardiovascular Research], Partner site Heidelberg/Mannheim, Heidelberg, Germany., Katus HA; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; DZHK [German Centre for Cardiovascular Research], Partner site Heidelberg/Mannheim, Heidelberg, Germany., Frey N; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; DZHK [German Centre for Cardiovascular Research], Partner site Heidelberg/Mannheim, Heidelberg, Germany., Geis NA; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany., Raake PWJ; Department of Internal Medicine III, Cardiology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; DZHK [German Centre for Cardiovascular Research], Partner site Heidelberg/Mannheim, Heidelberg, Germany.
المصدر: ESC heart failure [ESC Heart Fail] 2021 Oct; Vol. 8 (5), pp. 3530-3538. Date of Electronic Publication: 2021 Aug 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]-
مواضيع طبية MeSH: Cardiac Surgical Procedures* , Heart Valve Prosthesis Implantation* , Mitral Valve Insufficiency*/diagnosis , Mitral Valve Insufficiency*/epidemiology , Mitral Valve Insufficiency*/surgery, Aged ; Humans ; Male ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Treatment Outcome
مستخلص: Aims: We investigated short and mid-term safety and efficacy of the PASCAL system for percutaneous mitral valve repair (PMVr) in severe mitral regurgitation (MR) in an all-comer population.
Methods and Results: In the first consecutive 41 patients undergoing PMVr using the PASCAL system in our centre, procedural success and safety were assessed. Efficacy in improving MR and functional class were evaluated. Median patient age was 74 years, 58.5% were male patients, and median European System for Cardiac Operative Risk Evaluation Score II was 5.1%. All patients suffered from severe MR with 59% functional MR, 29% degenerative MR, and 12% of mixed aetiology MR. The technical success rate was 90%, limited by four cases where PASCAL implantation was aborted due to a prohibitive mitral gradient. On average, 1.16 PASCAL devices per patient were implanted. All patients successfully implanted with a PASCAL device were discharged with MR grade ≤ 2 and 79% with MR grade ≤ 1. Mean follow-up was 8.7 ± 4.9 months. Ninety-seven per cent of patients remained at MR ≤ 2 at follow-up, which translated into a significantly improved New York Heart Association functional class as well as a significant reduction of systolic pulmonary artery pressure and brain natriuretic peptide levels. The procedure-related rate for major adverse events was 3%. Neither early nor late single-leaflet detachment was found. In one patient, air embolism occurred, resulting in modification of the PASCAL instructions for use.
Conclusions: Percutaneous mitral valve repair using PASCAL in a real-world, all-comer population was feasible and safe, resulting in a significant mid-term reduction of MR with persistent clinical improvement.
(© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
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فهرسة مساهمة: Keywords: Edge-to-edge repair; Heart failure; Leaflet repair; Mitral valve regurgitation; Mitral valve repair; PASCAL device
تواريخ الأحداث: Date Created: 20210827 Date Completed: 20211028 Latest Revision: 20211028
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8497336
DOI: 10.1002/ehf2.13569
PMID: 34448541
قاعدة البيانات: MEDLINE
الوصف
تدمد:2055-5822
DOI:10.1002/ehf2.13569