دورية أكاديمية
Increasing sample diversity in psychiatric genetics - Introducing a new cohort of patients with schizophrenia and controls from Vietnam - Results from a pilot study.
| العنوان: | Increasing sample diversity in psychiatric genetics - Introducing a new cohort of patients with schizophrenia and controls from Vietnam - Results from a pilot study. |
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| المؤلفون: | Nguyen VT; Department of Psychiatry, Hanoi Medical University, Hà Nội, Việt Nam.; National Institute of Mental Health, Bach Mai Hospital, Hà Nội, Việt Nam., Braun A; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany., Kraft J; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany., Ta TMT; Berlin Institute of Health, Charité - Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Panagiotaropoulou GM; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany., Nguyen VP; Department of Psychiatry, Hanoi Medical University, Hà Nội, Việt Nam., Nguyen TH; Department of Psychiatry, Hanoi Medical University, Hà Nội, Việt Nam.; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Trubetskoy V; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany., Le CT; Department of Psychiatry, Hanoi Medical University, Hà Nội, Việt Nam.; National Institute of Mental Health, Bach Mai Hospital, Hà Nội, Việt Nam., Le TTH; Department of Psychiatry, Hanoi Medical University, Hà Nội, Việt Nam.; National Institute of Mental Health, Bach Mai Hospital, Hà Nội, Việt Nam., Pham XT; Department of Psychiatry, Hanoi Medical University, Hà Nội, Việt Nam., Heuser-Collier I; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Lam NH; Hanoi Mental Hospital, Hà Nội, Việt Nam., Böge K; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Hahne IM; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Bajbouj M; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Zierhut MM; Berlin Institute of Health, Charité - Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Hahn E; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Berlin, Germany., Ripke S; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. |
| المصدر: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2022 Mar; Vol. 23 (3), pp. 219-227. Date of Electronic Publication: 2021 Aug 27. |
| نوع المنشور: | Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Glasgow : WFSBP, 2000- |
| مواضيع طبية MeSH: | Schizophrenia*/genetics, Humans ; Genome-Wide Association Study ; Pilot Projects ; Genetic Predisposition to Disease ; Vietnam ; Multifactorial Inheritance |
| مستخلص: | Objectives: Genome-Wide Association Studies (GWAS) of Schizophrenia (SCZ) have provided new biological insights; however, most cohorts are of European ancestry. As a result, derived polygenic risk scores (PRS) show decreased predictive power when applied to populations of different ancestries. We aimed to assess the feasibility of a large-scale data collection in Hanoi, Vietnam, contribute to international efforts to diversify ancestry in SCZ genetic research and examine the transferability of SCZ-PRS to individuals of Vietnamese Kinh ancestry. Methods: In a pilot study, 368 individuals (including 190 SCZ cases) were recruited at the Hanoi Medical University's associated psychiatric hospitals and outpatient facilities. Data collection included sociodemographic data, baseline clinical data, clinical interviews assessing symptom severity and genome-wide SNP genotyping. SCZ-PRS were generated using different training data sets: (i) European, (ii) East-Asian and (iii) trans-ancestry GWAS summary statistics from the latest SCZ GWAS meta-analysis. Results: SCZ-PRS significantly predicted case status in Vietnamese individuals using mixed-ancestry (R 2 liability = 4.9%, p = 6.83 × 10 -8 ), East-Asian (R 2 liability = 4.5%, p = 2.73 × 10 -7 ) and European (R 2 liability = 3.8%, p = 1.79 × 10 -6 ) discovery samples. Discussion: Our results corroborate previous findings of reduced PRS predictive power across populations, highlighting the importance of ancestral diversity in GWA studies. |
| فهرسة مساهمة: | Keywords: East-Asia; GWAS; Schizophrenia; Vietnam; polygenic prediction |
| تواريخ الأحداث: | Date Created: 20210827 Date Completed: 20221026 Latest Revision: 20221101 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/15622975.2021.1951474 |
| PMID: | 34449294 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1814-1412 |
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| DOI: | 10.1080/15622975.2021.1951474 |