دورية أكاديمية
Alzheimer's disease: Is there a role for galectins?
| العنوان: | Alzheimer's disease: Is there a role for galectins? |
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| المؤلفون: | da Rosa MM; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil; Center for Therapeutic Innovation - Suelly Galdino (NUPIT-SG), Recife, Brazil. Electronic address: michelle.rosa@ufpe.br., de Aguiar Ferreira M; Federal University of Pernambuco, Recife, Brazil., de Oliveira Lima CA; Federal University of Pernambuco, Recife, Brazil., Santos Mendonça AC; Federal University of Pernambuco, Recife, Brazil., Silva YM; Federal University of Pernambuco, Recife, Brazil., Sharjeel M; King Edward Medical University, Lahore, Pakistan., de Melo Rego MJB; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil., Pereira MC; Center for Therapeutic Innovation - Suelly Galdino (NUPIT-SG), Recife, Brazil; Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil., da Rocha Pitta MG; Department of Biochemistry, Federal University of Pernambuco, Recife, Brazil. |
| المصدر: | European journal of pharmacology [Eur J Pharmacol] 2021 Oct 15; Vol. 909, pp. 174437. Date of Electronic Publication: 2021 Aug 24. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
| مواضيع طبية MeSH: | Alzheimer Disease/*immunology , Galectins/*metabolism , Neuroinflammatory Diseases/*immunology , Signal Transduction/*immunology, Alzheimer Disease/pathology ; Brain/immunology ; Brain/pathology ; Cytokines/metabolism ; Humans ; Microglia/immunology ; Microglia/pathology ; Neuroinflammatory Diseases/pathology |
| مستخلص: | Alzheimer's disease (AD) is the world's leading cause of neurological dysfunction, cognitive decline, and neuronal loss in the elderly. The sedimentation of beta amyloid (Aβ)-containing plaque, and formation of tau-containing neurofibrillary tangles (NFTs) along with extensive neuroinflammation, are the events that characterize the pathogenesis of AD. Galectins (gal) are carbohydrate-containing-ligand molecules recognized as potential modulators of the brain microglia polarization, immunosurveillance, neuroinflammation, and neuroprotection. Galectins 1, 3, 4, 8, and 9 are amongst the 15 members of the galectin family which are expressed in the brain. These galectins possess a significant correlation with neuromodulation through the glial cell-induced cytokine production that plays either a complementary or antagonistic role in the disturbance of the CNS physiology. Therefore, elaborating the hypothesis of galectins in the development of AD is of potential interest. This review aims at discussing the interaction between galectins and the neuropathophysiology of AD. An understanding about how galectins communicate with AD progression could lead to the development of improved diagnostic and therapeutic strategies for this leading cause of dementia worldwide. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer's disease; Galectins; Inflammation; Neuroprotection |
| المشرفين على المادة: | 0 (Cytokines) 0 (Galectins) |
| تواريخ الأحداث: | Date Created: 20210827 Date Completed: 20220124 Latest Revision: 20220124 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ejphar.2021.174437 |
| PMID: | 34450113 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0712 |
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| DOI: | 10.1016/j.ejphar.2021.174437 |