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Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System.

التفاصيل البيبلوغرافية
العنوان: Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System.
المؤلفون: de Freitas CL; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Polonio CM; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Brandão WN; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Rossato C; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Zanluqui NG; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo (USP), São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., de Oliveira LG; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., de Oliveira MG; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Evangelista LP; Reproductive Medicine Division, Célula Mater Clinic, São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Halpern S; Reproductive Medicine Division, Halpern Clinic, São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Maluf M; Reproductive Medicine Division, CEERH Clinic, São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Czresnia CE; Reproductive Medicine Division, Célula Mater Clinic, São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Perin P; Reproductive Medicine Division, CEERH Clinic, São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., de Almeida DC; Nephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil., Peron JPS; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730 Lab 232. Cidade Universitária, São Paulo, SP, CEP 05508-000, Brazil. jeanpierre@usp.br.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo (USP), São Paulo, Brazil. jeanpierre@usp.br.; Scientific Platform Pasteur-USP, University of São Paulo, São Paulo, Brazil. jeanpierre@usp.br.
المصدر: Stem cell reviews and reports [Stem Cell Rev Rep] 2022 Feb; Vol. 18 (2), pp. 609-625. Date of Electronic Publication: 2021 Aug 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : [New York, NY] : Springer Science+Business Media
Original Publication: [Totowa, N.J.] : Humana Press, [2009]-
مواضيع طبية MeSH: Encephalomyelitis, Autoimmune, Experimental*/therapy , Mesenchymal Stem Cells*, Adult ; Animals ; Central Nervous System ; Fallopian Tubes ; Female ; Humans ; Interleukin-10 ; Interleukin-4
مستخلص: Mesenchymal stem cells comprise a natural reservoir of undifferentiated cells within adult tissues. Given their self-renewal, multipotency, regenerative potential and immunomodulatory properties, MSCs have been reported as a promising cell therapy for the treatment of different diseases, including neurodegenerative and autoimmune diseases. In this study, we investigated the immunomodulatory properties of human tubal mesenchymal stem cells (htMSCs) using the EAE model. htMSCs were able to suppress dendritic cells activation downregulating antigen presentation-related molecules, such as MHCII, CD80 and CD86, while impairing IFN-γ and IL-17 and increasing IL-10 and IL-4 secretion. It further correlated with milder disease scores when compared to the control group due to fewer leukocytes infiltrating the CNS, specially Th1 and Th17 lymphocytes, associated with increased IL-10 secreting Tr1 cells. Conversely, microglia were less activated and infiltrating mononuclear cells secreted higher levels of IL-4 and IL-10 and expressed reduced chemokine receptors as CCR4, CCR6 and CCR8. qPCR of the spinal cords revealed upregulation of indoleamine-2,3-dioxygenase (IDO) and brain derived neurotrophic factor (BDNF). Taken together, here evidenced the potential of htMSCs as an alternative for the treatment of inflammatory, autoimmune or neurodegenerative diseases.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Dendritic cells; EAE; Immunomodulation; Lymphocytes; Mesenchymal stem cell
المشرفين على المادة: 130068-27-8 (Interleukin-10)
207137-56-2 (Interleukin-4)
تواريخ الأحداث: Date Created: 20210828 Date Completed: 20220421 Latest Revision: 20220421
رمز التحديث: 20221213
DOI: 10.1007/s12015-021-10226-7
PMID: 34453694
قاعدة البيانات: MEDLINE
الوصف
تدمد:2629-3277
DOI:10.1007/s12015-021-10226-7