دورية أكاديمية
أعرض في EDS

Enhancement of placental inflammation by Dibutyl Phthalate.

التفاصيل البيبلوغرافية
العنوان: Enhancement of placental inflammation by Dibutyl Phthalate.
المؤلفون: Alsubaie AM; Department of Foundations of Medicine, NYU-Long Island School of Medicine, Mineola, NY, 11501, United States; Department of Biology, Adelphi University, Garden City, NY, United States., Arita Y; Department of Foundations of Medicine, NYU-Long Island School of Medicine, Mineola, NY, 11501, United States., Atwater M; Department of Foundations of Medicine, NYU-Long Island School of Medicine, Mineola, NY, 11501, United States; George Washington University, School of Medicine, Washington DC, United States., Mahfuz A; Department of Foundations of Medicine, NYU-Long Island School of Medicine, Mineola, NY, 11501, United States; Texas Christian University University of North Texas Health Science Center School of Medicine, Fort Worth, TX, United States., Peltier MR; Department of Foundations of Medicine, NYU-Long Island School of Medicine, Mineola, NY, 11501, United States. Electronic address: mpeltier@winthrop.org.
المصدر: Journal of reproductive immunology [J Reprod Immunol] 2021 Sep; Vol. 147, pp. 103368. Date of Electronic Publication: 2021 Aug 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 8001906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7603 (Electronic) Linking ISSN: 01650378 NLM ISO Abbreviation: J Reprod Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Dibutyl Phthalate/*toxicity , Environmental Pollutants/*toxicity , Placenta/*immunology , Pregnancy Complications, Infectious/*chemically induced, Brain-Derived Neurotrophic Factor/metabolism ; Female ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Inflammation/chemically induced ; Inflammation/immunology ; Inflammation/pathology ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Placenta/drug effects ; Placenta/metabolism ; Placenta/pathology ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/pathology ; Primary Cell Culture/methods ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: Recent studies suggest that women with high exposures to dibutyl phthalate (DBP) are at increased risk for preterm birth, a condition associated with aberrant inflammation in the placenta often caused by subclinical infections. Placental inflammation is also a risk factor for neurodevelopmental disorders whose risk may also be enhanced by DBP. It is unclear, however, if DBP enhances placental inflammation. Therefore, we studied the effects of DBP on the production of biomarkers of placental inflammation and neurodevelopment under basal conditions and a setting of mild infection. Placental explant cultures established from women undergoing elective caesarean delivery were treated with DBP with and without co-stimulation by 10 7 CFU/mL heat-killed E. coli for 24 h at 37 °C. Conditioned medium was harvested and concentrations of IL-1β, TNF-α, IL-10, HO-1 and BDNF, a biomarker for neurodevelopment, were quantified. DBP significantly enhanced IL-6 production in basal cultures but had no significant on the other biomarkers quantified. Both TNF-α and IL-1β production was enhanced by DBP for cultures co-stimulated with E. coli. Although marginal enhancement of IL-6, and IL-10 were observed for bacteria co-treated cultures, results were either non-monotonic or only approached statistical significance. HO-1 production tended to be reduced at the highest concentration of DBP tested and BDNF production was reduced by DBP in a dose-dependent manner for bacteria-stimulated cultures. These results suggest that DBP enhances basal IL-6 production but has little or no effect on other biomarkers studied. However, DBP enhances IL-1β and TNF-α production but reduces BDNF production by bacteria-stimulated cultures.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Dibutyl phthalate; Host-immune response; Infection; Inflammation; Phthalates
المشرفين على المادة: 0 (Brain-Derived Neurotrophic Factor)
0 (Environmental Pollutants)
0 (IL1B protein, human)
0 (IL6 protein, human)
0 (Interleukin-1beta)
0 (Interleukin-6)
0 (TNF protein, human)
0 (Tumor Necrosis Factor-alpha)
2286E5R2KE (Dibutyl Phthalate)
7171WSG8A2 (BDNF protein, human)
تواريخ الأحداث: Date Created: 20210830 Date Completed: 20220201 Latest Revision: 20220201
رمز التحديث: 20240628
DOI: 10.1016/j.jri.2021.103368
PMID: 34461555
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7603
DOI:10.1016/j.jri.2021.103368