دورية أكاديمية
Synbiotic supplementation attenuates the promoting effect of indole-3-carbinol on colon tumorigenesis.
| العنوان: | Synbiotic supplementation attenuates the promoting effect of indole-3-carbinol on colon tumorigenesis. |
|---|---|
| المؤلفون: | de Moura NA; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Prof. Dr. Antônio Celso Wagner Zanin 250, Distrito de Rubião Junior, Botucatu, SP, Brazil., Caetano BFR; Department of Pathology, School of Medicine, Sao Paulo State University (UNESP), Botucatu, SP, Brazil., Bidinotto LT; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.; Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, Barretos, SP, Brazil.; Department of Pathology, School of Medicine, Sao Paulo State University (UNESP), Botucatu, SP, Brazil., Rodrigues MAM; Department of Pathology, School of Medicine, Sao Paulo State University (UNESP), Botucatu, SP, Brazil., Barbisan LF; Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Prof. Dr. Antônio Celso Wagner Zanin 250, Distrito de Rubião Junior, Botucatu, SP, Brazil. |
| المصدر: | Beneficial microbes [Benef Microbes] 2021 Oct 11; Vol. 12 (5), pp. 493-501. Date of Electronic Publication: 2021 Aug 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wageningen Academic Publishers Country of Publication: Netherlands NLM ID: 101507616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-2891 (Electronic) Linking ISSN: 18762883 NLM ISO Abbreviation: Benef Microbes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wageningen : Wageningen Academic Publishers |
| مواضيع طبية MeSH: | Carcinogenesis*/drug effects , Colonic Neoplasms*/prevention & control , Indoles*/adverse effects , Synbiotics*, Animals |
| مستخلص: | Indole-3 carbinol (I3C) has shown dual effects on the promotion and progression stages of colon carcinogenesis while synbiotics (Syn) have exerted anti-carcinogenic activities in most rodent studies. This study aimed to investigate the effects of I3C given alone or together with a Syn intervention on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis. All animals were given four subcutaneous DMH injections (4×40 mg/kg bodyweight, twice a week for two weeks) and then received either basal diet (G1), basal diet containing I3C (1g/kg chow) (G2) or basal diet containing I3C+Syn (I3C + inulin 50g/kg chow + Bifidobacterium lactis BB-12 ® ), 2.5×10 10 cfu/g of basal diet), (G3) for 21 weeks. Dietary I3C (G2) significantly increased tumour volume and cell proliferation when compared to the DMH control group (G1). Syn intervention (G3) significantly reduced tumour volume and cell proliferation when compared to I3C (G2). The colon tumours found were classified into well-differentiated tubular adenomas or adenocarcinomas. Dietary I3C or I3C+Syn did not significantly affect the incidence and the multiplicity of tumours in comparison with the DMH control group. Furthermore, Syn intervention (G3) increased Gstm1 and reduced Mapk9 gene expression in colonic tumours. The findings of the present study show that the dietary I3C shows a weak promoting activity, while the combination with Syn ameliorates I3C effects. |
| فهرسة مساهمة: | Keywords: 1,2-dimethylhydrazine; Bifidobacterium lactis BB-12; colon carcinogenesis; colorectal cancer |
| المشرفين على المادة: | C11E72455F (indole-3-carbinol) 0 (Indoles) |
| تواريخ الأحداث: | Date Created: 20210831 Date Completed: 20221229 Latest Revision: 20221229 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3920/BM2020.0209 |
| PMID: | 34463193 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-2891 |
|---|---|
| DOI: | 10.3920/BM2020.0209 |