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Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.

التفاصيل البيبلوغرافية
العنوان: Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.
المؤلفون: Reilly DK; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.; Tufts University, Medford, MA, USA., McGlame EJ; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.; AbbVie Foundational Neuroscience Center, Cambridge, MA, USA., Vandewyer E; Neural Signaling and Circuit Plasticity Group, Department of Biology, KU Leuven, Leuven, Belgium., Robidoux AN; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA., Muirhead CS; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA., Northcott HT; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.; Optum, Hartford, CT, USA., Joyce W; Neurobiology Department, University of Massachusetts Medical School, Worcester, MA, USA., Alkema MJ; Neurobiology Department, University of Massachusetts Medical School, Worcester, MA, USA., Gegear RJ; Department of Biology, University of Massachusetts Dartmouth, Dartmouth, MA, USA., Beets I; Neural Signaling and Circuit Plasticity Group, Department of Biology, KU Leuven, Leuven, Belgium., Srinivasan J; Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA. jsrinivasan@wpi.edu.
المصدر: Communications biology [Commun Biol] 2021 Aug 31; Vol. 4 (1), pp. 1018. Date of Electronic Publication: 2021 Aug 31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
مواضيع طبية MeSH: Locomotion*/drug effects, Caenorhabditis elegans/*physiology , Hermaphroditic Organisms/*physiology , Receptors, Neuropeptide/*genetics, Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins ; Carrier Proteins ; Hermaphroditic Organisms/genetics ; Male ; Receptors, Neuropeptide/metabolism
مستخلص: Dioecious species are a hallmark of the animal kingdom, with opposing sexes responding differently to identical sensory cues. Here, we study the response of C. elegans to the small-molecule pheromone, ascr#8, which elicits opposing behavioral valences in each sex. We identify a novel neuropeptide-neuropeptide receptor (NP/NPR) module that is active in males, but not in hermaphrodites. Using a novel paradigm of neuropeptide rescue that we established, we leverage bacterial expression of individual peptides to rescue the sex-specific response to ascr#8. Concurrent biochemical studies confirmed individual FLP-3 peptides differentially activate two divergent receptors, NPR-10 and FRPR-16. Interestingly, the two of the peptides that rescued behavior in our feeding paradigm are related through a conserved threonine, suggesting that a specific NP/NPR combination sets a male state, driving the correct behavioral valence of the ascr#8 response. Receptor expression within pre-motor neurons reveals novel coordination of male-specific and core locomotory circuitries.
(© 2021. The Author(s).)
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معلومات مُعتمدة: R01 DC016058 United States DC NIDCD NIH HHS; R01 GM140480 United States GM NIGMS NIH HHS; R01 NS107475 United States NS NINDS NIH HHS; P40 OD010440 United States OD NIH HHS
المشرفين على المادة: 0 (Caenorhabditis elegans Proteins)
0 (Carrier Proteins)
0 (Receptors, Neuropeptide)
0 (nud-2 protein, C elegans)
تواريخ الأحداث: Date Created: 20210901 Date Completed: 20211207 Latest Revision: 20230413
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8408276
DOI: 10.1038/s42003-021-02547-7
PMID: 34465863
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-3642
DOI:10.1038/s42003-021-02547-7