دورية أكاديمية
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Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.

التفاصيل البيبلوغرافية
العنوان: Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
المؤلفون: Gibb AA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Murray EK; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Eaton DM; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Huynh AT; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Tomar D; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Garbincius JF; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Kolmetzky DW; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Berretta RM; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Wallner M; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.; Division of Cardiology, Medical University of Graz, Graz, Austria.; Center for Biomarker Research in Medicine, CBmed GmbH, Graz, Austria., Houser SR; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA., Elrod JW; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2021 Aug 23; Vol. 6 (8), pp. 650-672. Date of Electronic Publication: 2021 Aug 23 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression.
Competing Interests: This work was supported in part by National Institutes of Health (NIH) grants R01HL123966, R01HL136954, R01HL142271, and P01HL134608 (Dr Elrod); American Heart Association grant 20EIA35320226 (Dr Elrod), NIH grant F32HL145914 (Dr Gibb), and NIH grant F31HL143913 (Ms Murray), NIH grant K99DK120876 ( Dr Tomar), NIH grants T32HL091804, F32HL151146 (Dr Garbinicius), and NIH grant R01HL147558 (Dr Houser). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(© 2021 The Authors.)
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معلومات مُعتمدة: F32 HL151146 United States HL NHLBI NIH HHS; K99 DK120876 United States DK NIDDK NIH HHS; R01 HL147558 United States HL NHLBI NIH HHS; T32 HL091804 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: BCAA, branched chain amino acids; DAG, diacylglycerol; ECM, extracellular matrix; EF, ejection fraction; ESI, electrospray ionization; ETC, electron transport chain; FC, fold change; FDR, false discovery rate; GO, gene ontology; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LA, left atrial; LAV, left atrial volume; LV, left ventricle/ventricular; MS/MS, tandem mass spectrometry; RCR, respiratory control ratio; RI, retention index; UPLC, ultraperformance liquid chromatography; heart failure; m/z, mass to charge ratio; metabolomics; mitochondria; preserved ejection fraction; systems biology; transcriptomics
تواريخ الأحداث: Date Created: 20210901 Latest Revision: 20221229
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8385567
DOI: 10.1016/j.jacbts.2021.07.004
PMID: 34466752
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2021.07.004