دورية أكاديمية
أعرض في EDS

Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions.

التفاصيل البيبلوغرافية
العنوان: Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions.
المؤلفون: Bonetti TCS; Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Centro de Neurociencias e Saude da Mulher 'Professor Geraldo Rodrigues de Lima', Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR., Latini FRM; Associacao Beneficente de Coleta de Sangue (COLSAN), Sao Paulo, SP, BR., Invitti AL; Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Centro de Neurociencias e Saude da Mulher 'Professor Geraldo Rodrigues de Lima', Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Associacao Beneficente de Coleta de Sangue (COLSAN), Sao Paulo, SP, BR., Fonseca MCM; Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Centro de Neurociencias e Saude da Mulher 'Professor Geraldo Rodrigues de Lima', Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR., Scorza FA; Centro de Neurociencias e Saude da Mulher 'Professor Geraldo Rodrigues de Lima', Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Disciplina de Neurociencia, Departamento de Neurologia/Neurocirurgia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR., Saldanha MG; Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR., Bellucco FT; EUROIMMUN Brasil, Sao Caetano do Sul, SP, BR., Bacarov NBS; EUROIMMUN Brasil, Sao Caetano do Sul, SP, BR., Soane MM; EUROIMMUN Brasil, Sao Caetano do Sul, SP, BR., Girão MJBC; Laboratorio de Ginecologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Centro de Neurociencias e Saude da Mulher 'Professor Geraldo Rodrigues de Lima', Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP, BR.; Associacao Beneficente de Coleta de Sangue (COLSAN), Sao Paulo, SP, BR.
المصدر: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2021 Aug 27; Vol. 76, pp. e2818. Date of Electronic Publication: 2021 Aug 27 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
مواضيع طبية MeSH: COVID-19*/therapy , Coronavirus Infections*, Antibodies, Viral ; Humans ; Immunization, Passive ; SARS-CoV-2 ; COVID-19 Serotherapy
مستخلص: Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies' ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies.
Methods: This study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms.
Results: Anti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms.
Conclusions: Our study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered.
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المشرفين على المادة: 0 (Antibodies, Viral)
تواريخ الأحداث: Date Created: 20210901 Date Completed: 20210906 Latest Revision: 20221207
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8366902
DOI: 10.6061/clinics/2021/e2818
PMID: 34468538
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5322
DOI:10.6061/clinics/2021/e2818