دورية أكاديمية
أعرض في EDS

Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders.

التفاصيل البيبلوغرافية
العنوان: Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders.
المؤلفون: Chai Y; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Chimelis-Santiago JR; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Bixler KA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA., Aalsma M; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA., Yu M; Indiana Alzheimer Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Network Science Institute, Bloomington, IN, USA., Hulvershorn LA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: lhulvers@iu.edu.
المصدر: NeuroImage. Clinical [Neuroimage Clin] 2021; Vol. 32, pp. 102789. Date of Electronic Publication: 2021 Aug 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101597070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1582 (Electronic) Linking ISSN: 22131582 NLM ISO Abbreviation: Neuroimage Clin Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier
مواضيع طبية MeSH: Corpus Striatum*/diagnostic imaging , Sex Characteristics*, Adolescent ; Amygdala ; Child ; Female ; Humans ; Impulsive Behavior ; Magnetic Resonance Imaging ; Male ; Neural Pathways/diagnostic imaging ; Prefrontal Cortex/diagnostic imaging
مستخلص: Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with attention-deficit/hyperactivity disorder (ADHD).
Methods: The current study used functional magnetic resonance imaging(fMRI) to examine sex differences in resting-state seed-based FC, self-rated impulsivity, and their interactions in 11-12-year-old boys (n = 43) and girls (n = 43) with externalizing disorders. Generalized linear models controlling for pubertal development were used. Seeds were chosen in the ventral striatum, medial prefrontal cortex, middle frontal gyrus and amygdala.
Results: Impulsivity scores were greater in boys than girls (p < 0.05). Boys showed greater positive connectivity within a ventromedial prefrontal-ventral striatal network. In addition, boys demonstrated weaker connectivity than girls within two medial-lateral prefrontal cortical networks. However, only boys showed greater medial-lateral prefrontal connectivity correlated with greater impulsivity.
Conclusions: The findings provide evidence supporting sex differences in both ventral striatal-ventromedial prefrontal and medial-lateral prefrontal functional networks in youth with externalizing disorders. These important networks are thought to be implicated in impulse control. Medial-lateral prefrontal connectivity may represent a male-specific biomarker of impulsivity.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 DA039764 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: Adolescence; Externalizing disorders; Frontal-striatal Connectivity; Impulsivity; Resting-state Functional Connectivity; Sex Differences
تواريخ الأحداث: Date Created: 20210901 Date Completed: 20220119 Latest Revision: 20230505
رمز التحديث: 20230506
مُعرف محوري في PubMed: PMC8405840
DOI: 10.1016/j.nicl.2021.102789
PMID: 34469847
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-1582
DOI:10.1016/j.nicl.2021.102789