دورية أكاديمية

The Association of Reproductive Aging with Cognitive Function in Sub-Saharan African Women.

التفاصيل البيبلوغرافية
العنوان: The Association of Reproductive Aging with Cognitive Function in Sub-Saharan African Women.
المؤلفون: Jaff NG; Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. nrj1@mweb.co.za., Crowther NJ; Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2343, pp. 71-91.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,
مواضيع طبية MeSH: Aging* , Cognition* , Cognition Disorders*/epidemiology , Quality of Life*, Africa South of the Sahara/epidemiology ; Female ; Humans ; Menopause
مستخلص: Life expectancy in sub-Saharan African women is increasing, and by the late 2020s an estimated 76% of postmenopausal women globally will be living in developing countries. Menopause transition has been associated with cognitive decline in a wide range of studies, but data on cognition and reproductive aging are lacking in sub-Saharan African women. Approximately 72 million people in the region are expected to suffer from dementias and neurocognitive decline by 2050. Studies show that compromised cognitive health in low-income countries has significant implications for adult quality of life and socioeconomic development. There is now an urgent need to further examine risk factors for cognitive decline in these aging women and to understand the ability of public health programs to diagnose and treat cognitive dysfunction. This review examines studies assessing cognition and aging in sub-Saharan African adults, while addressing the significant research gaps. It examines data on the association of the menopause transition with cognitive function and describes how validated tools should be available to assess both menopausal stage and symptoms. Culturally appropriate and validated neurocognitive measures are required to better understand the relationship of reproductive aging with cognition. Longitudinal population-based studies are needed to assess the effect of lifestyle interventions, such as diet and exercise, on cognitive health in sub-Saharan African populations, with an emphasis on women as they transition into menopause.
(© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
References: Kobayashia LC, Mateenc FJ, Montana L, Wagner RG, Kahn K, Tollman SM et al (2019) Cognitive function and impairment in older, rural South African adults: evidence from “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in Rural South Africa”. Neuroepidemiology 52:32–40. (PMID: 10.1159/000493483)
Hill K (1996) The demography of menopause. Maturitas 23:113–117. (PMID: 873535010.1016/0378-5122(95)00968-X8735350)
Barrett-Connor BH, Collins P, Coope P, Coope J, Dennerstein L et al (1996) World Health Organization research on menopause: report of a WHO scientific group. WHO Tech Rep 866:1–116.
Haan MN (2001) Women’s health. In: Smelser NJ, Baltes PB (eds) International encyclopedia of the social & behavioral sciences. Elsevier, Amsterdam, pp 16528–16532. Hardcover ISBN: 9780080430768. (PMID: 10.1016/B0-08-043076-7/03866-3)
Velez MP, Alvarado BE, Lord C, Zunzunegui MV (2010) Life course socioeconomic adversity and age at natural menopause in women from Latin America and the Caribbean. Menopause 17:552–559. (PMID: 2046478410.1097/gme.0b013e3181ceca7a20464784)
Shuster L, Rhodes D, Gostout B, Grossardt B, Rocca W (2010) Premature menopause or early menopause: long-term health consequences. Maturitas 65:161–166. (PMID: 1973398810.1016/j.maturitas.2009.08.00319733988)
Wellons M, Ouyang P, Schreiner PJ, Herrington DM, Vaidya D (2012) Early menopause predicts future coronary heart disease and stroke: the multi-ethnic study of atherosclerosis. Menopause 19:1081–1087. (PMID: 22692332344354010.1097/gme.0b013e3182517bd0)
Weber MT, Maki PM, McDermott MP (2014) Cognition and mood in perimenopause: a systematic review and meta-analysis. J Steroid Biochem Mol Biol 142:90–98. (PMID: 2377032010.1016/j.jsbmb.2013.06.00123770320)
Jaff NG, Rubin LJ, Crowther NJ, Norris SA, Maki PM (2019) Menopausal symptoms, menopausal stage and cognitive functioning in black urban African women. Climacteric 23:1–8.
Payne C, Kohler IV, Bandawe C, Lawler K, Kohler HP (2018) Cognition, health, and well-being in a rural Sub-Saharan African population. Eur J Popul 34:637–662. (PMID: 3038177810.1007/s10680-017-9445-130381778)
Hahn RA, Eaker E, Rolka H (1997) Reliability of reported age at menopause. Am J Epidemiol 146:771–775. (PMID: 936662510.1093/oxfordjournals.aje.a0093539366625)
Rodstrom K, Bengtsson C, Lissner L, Bjorkelund C (2005) Reproducibility of self-reported menopause age at the 24-year follow-up of a population study of women in Goteborg, Sweden. Menopause 12:275–280. (PMID: 1587991610.1097/01.GME.0000135247.11972.B315879916)
Sievert LL (2005) Recalling age at menopause. Menopause 12:248–249. (PMID: 1587991210.1097/01.GME.0000163191.19167.5B15879912)
Paramsothy P, Harlow SD, Elliott MR, Lisabeth LD, Crawford SL, Randolph JF (2013) Classifying menopause stage by menstrual calendars and annual interviews: need for improved questionnaires. Menopause 20:727–735. (PMID: 23481122368699510.1097/GME.0b013e3182825ff2)
Jaff NG, Snyman T, Norris SA, Crowther NJ (2014) Staging reproductive aging using stages of reproductive aging workshop + 10 in black urban African women in the Study of Women Entering and in Endocrine Transition. Menopause 21:1225–1233. (PMID: 2473619910.1097/GME.000000000000023524736199)
Greendale GA, Wight RG, Huang MH, Avis N, Gold EB, Joffe H et al (2010) Menopause-associated symptoms and cognitive performance: results from the study of women’s health across the nation. Am J Epidemiol 171:1214–1224. (PMID: 20442205291549210.1093/aje/kwq067)
Greendale G, Huang M, Wight R, Seeman T, Luetters C, Avis N et al (2009) Effects of the menopause transition and hormone use on cognitive performance in midlife women. Neurology 72:1850–1857. (PMID: 19470968269098410.1212/WNL.0b013e3181a71193)
Epperson CN, Sammel MD, Freeman EW (2013) Menopause effects on verbal memory: findings from a longitudinal community cohort. J Clin Endocrinol Metab 98:3829–3838. (PMID: 23836935376398110.1210/jc.2013-1808)
Weber MT, Rubin LH, Maki PM (2013) Cognition in perimenopause: the effect of transition stage. Menopause 20:511–517. (PMID: 2361564210.1097/gme.0b013e31827655e5)
Rubin LH, Sundermann EE, Cook JA, Martin EM, Golub ET, Weber KM et al (2014) Investigation of menopausal stage and symptoms on cognition in human immunodeficiency virus-infected women. Menopause 21:997–1006. (PMID: 24496085411986710.1097/GME.0000000000000203)
Greendale GA, Derby CA, Maki PM (2011) Perimenopause and cognition. Obstet Gynecol Clin N Am 38:519–535. (PMID: 10.1016/j.ogc.2011.05.007)
Kok HS, Kuh D, Cooper R, van der Schouw YT, Grobbee DE, Wadsworth MEJ et al (2006) Cognitive function across the life course and the menopausal transition in a British birth cohort. Menopause 13:19–27. (PMID: 1660709510.1097/01.gme.0000196592.36711.a016607095)
Kuh D, Cooper R, Moore A, Richards M, Hardy R (2018) Age at menopause and lifetime cognition: findings from a British birth cohort study. Neurology 90:e1673–e1e81. (PMID: 29643079595297210.1212/WNL.0000000000005486)
Matyi JM, Rattinger GB, Schwartz S, Buhusi M, Tschanz JT (2019) Lifetime estrogen exposure and cognition in late life: the Cache County Study. Menopause 26:1366–1374. (PMID: 31613825744853810.1097/GME.0000000000001405)
Schaafsma M, Homewood J, Taylor A (2010) Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes. Climacteric 13:84–98. (PMID: 1972211810.3109/1369713090300918719722118)
Ryan J, Scali J, Carrière I, Amieva H, Rouaud O, Berr C et al (2014) Impact of a premature menopause on cognitive function in later life. Brit J Obstet Gynaec 121:1729–1739. (PMID: 10.1111/1471-0528.12828)
Ryan J, Carrière I, Scali J, Ritchie K, Ancelin M-L (2009) Life-time estrogen exposure and cognitive functioning in later life. Psychoneuroendocrinology 34:287–298. (PMID: 1894793410.1016/j.psyneuen.2008.09.00818947934)
Song X, Wu J, Zhou Y, Feng L, Yuan JM, Pan A et al (2020) Reproductive and hormonal factors and risk of cognitive impairment among Singapore Chinese women. Am J Obstet Gynecol S0002-9378(20):30220–30229. https://doi.org/10.1016/j.ajog.2020.02.032. (PMID: 10.1016/j.ajog.2020.02.032)
Terauchi M, Hirose A, Akiyoshi M, Owa Y, Kato K, Kubota T (2014) Subgrouping of Japanese middle-aged women attending a menopause clinic using physical and psychological symptom profiles: a cross-sectional study. BMC Womens Health 14:148. https://doi.org/10.1186/s12905-014-0148-z. (PMID: 10.1186/s12905-014-0148-z254209114247616)
McLay RN, Maki PM, Lyketsos CG (2003) Nulliparity and late menopause are associated with decreased cognitive decline. J Neuropsychiatry Clin Neurosci 15:161–167. (PMID: 1272445610.1176/jnp.15.2.16112724456)
Thomas F, Renaud F, Benefice E, De Meeüs T (2001) International variability of ages at menarche and menopause: patterns and main determinants. Hum Biol 73:271–290. (PMID: 1144642910.1353/hub.2001.002911446429)
Zunzunegui MV, Alvarado BE, Béland F, Bilkis VB (2009) Explaining health differences between men and women in later life: a cross-city comparison in Latin America and the Caribbean. Soc Sci Med 68:235–242. (PMID: 1903648810.1016/j.socscimed.2008.10.031)
Avis NE, Crawford SL (2001) Menopause and weight. Menopause 8:230–232. (PMID: 1144907810.1097/00042192-200107000-00002)
Freeman EW, Sherif K (2007) Prevalence of hot flushes and night sweats around the world: a systematic review. Climacteric 10:197–214. (PMID: 1748764710.1080/1369713060118148617487647)
Lerner-Geva L, Boyko V, Blumstein T, Benyamini Y (2010) The impact of education, cultural background, and lifestyle on symptoms of the menopausal transition: the Women’s Health at Midlife Study. J Women’s Health 19:975–985. (PMID: 10.1089/jwh.2009.1381)
Sievert LL (2012) Cross-cultural comparisons: methodological concerns. Menopause 19:1289–1290. (PMID: 2313225110.1097/gme.0b013e318271f600)
Soules MR (2005) Development of a staging system for the menopause transition: a work in progress. Menopause 12:117–120. (PMID: 1577255410.1097/00042192-200512020-0000115772554)
Harlow SD, Gass M, Hall JE, Lobo RA, Maki PM, Rebar RW et al (2012) Executive summary of the stages of reproductive aging workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause 19:387–395. (PMID: 22343510334090310.1097/gme.0b013e31824d8f40)
Randolph JF, Zheng H, Sowers MR, Crandall C, Crawford S, Gold EB et al (2011) Changes in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab 96:746–754. (PMID: 2115984210.1210/jc.2010-174621159842)
Van Voorhis BJ, Santoro N, Harlow SD, Crawford SL, Randolph JF (2008) The relationship of bleeding patterns to daily reproductive hormones in women approaching menopause. Obstet Gynecol 112:101–108. (PMID: 18591314266605010.1097/AOG.0b013e31817d452b)
Garnett ER, Jariwala P, Rector K, Gibbons WE, Zarutskie PW, Devaraj S (2019) Validation of the picoAMH assay on the Dynex DS2 platform. Pract Lab Med 17:e00140. https://doi.org/10.1016/j.plabm.2019.e00140. (PMID: 10.1016/j.plabm.2019.e00140316461666804432)
Harlow SD, Crawford S, Dennerstein L, Burger HG, Mitchell ES, Sowers MF (2007) Recommendations from a multi-study evaluation of proposed criteria for staging reproductive aging. Climacteric 10:199–206. (PMID: 10.1080/13697130701258838)
Schneider HP, Heinemann LA, Rosemeier HP, Potthoff P, Behre HM (2000) Reliability of scores of menopausal complaints. Climacteric 3:59–64. (PMID: 1191061110.3109/13697130009167600)
Heinemann LA, Potthoff P, Schneider HP (2003) International versions of the Menopause Rating Scale (MRS). Health Qual Life Outcomes 1:28. https://doi.org/10.1186/1477-7525-1-28. (PMID: 10.1186/1477-7525-1-2812914663183844)
El Shafie K, Al Farsi Y, Al Zadjali N, Al Adawi S, Al Busaidi Z, Al Shafaee M (2011) Menopausal symptoms among healthy, middle-aged Omani women as assessed with the Menopause Rating Scale. Menopause 18:113–119.
OlaOlorun FM, Lawoyin TO (2009) Experience of menopausal symptoms by women in an urban community in Ibadan, Nigeria. Menopause 16:822–830. (PMID: 1924238510.1097/gme.0b013e318198d6e719242385)
Jaff NG, Norris SA, Snyman T, Toman M, Crowther NJ (2015) Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): a perspective of African women who have a high prevalence of obesity and HIV infection. Metabolism 64:1031–1041. (PMID: 2603150610.1016/j.metabol.2015.05.009)
Im EO, Hu Y, Cheng CY, Ko Y, Chee E, Chee W (2019) Racial/ethnic differences in cognitive symptoms during the menopausal transition. West J Nurs Res 41:217–237. (PMID: 2960608510.1177/019394591876766029606085)
Santoro N, Lasley B, McConnell D, Allsworth JE, Crawford S, Gold EB et al (2004) Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: the Study of Women’s Health across the Nation (SWAN) Daily Hormone Study. J Clin Endocrinol Metab 89:2622–2631. (PMID: 1518103310.1210/jc.2003-03157815181033)
Randolph JF, Sowers MF, Gold EB, Mohr BA, Luborsky J, Santoro N et al (2003) Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab 88:1516–1522. (PMID: 1267943210.1210/jc.2002-02077712679432)
Gold EB, Sternfeld JL, Kelsey C, Brown C, Mouton N, Reame L et al (2000) Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40−55 years of age. Am J Epidemiol 152:463–473. (PMID: 1098146110.1093/aje/152.5.46310981461)
Richard-Davis G, Wellons M (2013) Racial and ethnic differences in the physiology and clinical symptoms of menopause. Semin Reprod Med 31:380–386. (PMID: 2393469910.1055/s-0033-134889723934699)
Drogos LL, Rubin LH, Geller SE, Banuvar S, Shulman LP, Maki PM (2013) Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms. Menopause 20:1236–1242. (PMID: 2367663310.1097/GME.0b013e318291f5a623676633)
Lekoubou A, Echouffo-Tcheugui JB, Kengne AP (2014) Epidemiology of neurodegenerative diseases in sub-Saharan Africa: a systematic review. BMC Public Health 14:653. https://doi.org/10.1186/1471-2458-14-653. (PMID: 10.1186/1471-2458-14-653249696864094534)
Mavrodaris A, Powell J, Thorogood M (2013) Prevalences of dementia and cognitive impairment among older people in sub-Saharan Africa: a systematic review. Bull World Health Organ 91:773–783. (PMID: 24115801379165810.2471/BLT.13.118422)
Houle B, Gaziano T, Farrell M, Gómez-Olivé FX, Kobayashi LC, Crowther NJ et al (2019) Cognitive function and cardiometabolic disease risk factors in rural South Africa: baseline evidence from the HAALSI study. BMC Public Health 19(1):1579. https://doi.org/10.1186/s12889-019-7938-z. (PMID: 10.1186/s12889-019-7938-z317757136882146)
Tianyi F, Agbor VN, Njamnshi AK (2019) Factors associated with the prevalence of cognitive impairment in a rural elderly Cameroonian population: a community-based study in sub-Saharan Africa. Dement Geratr Cogn Disord 47:104–113. (PMID: 10.1159/000496825)
Sutton-Tyrrell K, Zhao X, Santoro N, Lasley B, Sowers MF, Johnston J et al (2010) Reproductive hormones and obesity: 9 years of observation from the Study of Women’s Health Across the Nation. Am J Epidemiol 171:1203–1213. (PMID: 20427327291549010.1093/aje/kwq049)
Dye L, Boyle NB, Champ C, Lawton C (2017) The relationship between obesity and cognitive health and decline. Proc Nutr Soc 76:443–445. (PMID: 2888982210.1017/S002966511700201428889822)
Andany N, Logan Kennedy V, Aden M, Loutfy M (2016) Perspectives on menopause and women with HIV. Int J Women’s Health 11:1–22.
Shisana O, Rehle T, Simbayi LC, Lapadarios D, Jooste S, Davids A et al (2014) South African national HIV prevalence, incidence and behaviour survey, 2012. Human Sciences Research Council, Cape Town.
Maki PM, Rubin LH, Valcour V, Martin E, Crystal H, Young M et al (2014) Cognitive function in women with HIV: findings from the Women’s Interagency HIV study. Neurology 84:231–240. (PMID: 2554030410.1212/WNL.000000000000115125540304)
Conde DM, Silva ET, Amaral WN, Finotti MF, Ferreira RG, Costa-Paiva L et al (2009) HIV, reproductive aging, and health implications in women: a literature review. Menopause 16:199–123. (PMID: 1880001710.1097/gme.0b013e318177352c18800017)
Maki PM, Martin-Thormeyer E (2009) HIV, cognition and women. Neuropsychol Rev 19:204–214. (PMID: 19430907371645210.1007/s11065-009-9093-2)
Rubin LH, Cook JA, Weber KM, Cohen MH, Martin E, Valcour V et al (2015) The association of perceived stress and verbal memory is greater in HIV-infected versus HIV-uninfected women. J Neurovirol 21:422–432. (PMID: 25791344456221010.1007/s13365-015-0331-5)
Spies G, Fennema-Notestine C, Cherner M, Seedat S (2017) Changes in cognitive function in women with HIV infection and early life stress. AIDS Care 29:14–23. (PMID: 2739698010.1080/09540121.2016.120441727396980)
Rice K, Morse C (2003) Measuring cognition in menopause research: a review of test use. Climacteric 6:2–22. (PMID: 1272566010.1080/cmt.6.1.2.2212725660)
Humphreys GW, Duta MD, Montana L, Demeyere N, McCrory C, Rohr J et al (2017) Cognitive function in low-income and low-literacy settings: validation of the tablet-based Oxford cognitive screen in the health and aging in Africa: a longitudinal study of an INDEPTH Community in South Africa (HAALSI). J Gerontol B Psychol Sci Soc Sci 72:38–50. (PMID: 2797447410.1093/geronb/gbw13927974474)
Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M et al (2006) Global prevalence of dementia: a Delphi consensus study. Lancet 366:2112–2117. (PMID: 10.1016/S0140-6736(05)67889-0)
Ng KP, Chiew HJ, Lim L, Rosa-Neto P, Kandiah N, Gauthier S (2018) The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia. Expert Rev Neurother 18:859–869. (PMID: 3028668110.1080/14737175.2018.153279230286681)
Wildman RP, Wang D, Fernandez I, Mancuso P, Santoro N, Scherer PE et al (2013) Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. Obesity 18:629–636. (PMID: 10.1002/oby.20256)
Cassimjeee N, Motswai PK (2017) Neuropsychological profiles of adults and older adults with HIV. S Afr J Psych 47:35–45. (PMID: 10.1177/0081246316646296)
Burger HG, Hale GE, Dennerstein L, Robertson DM (2008) Cycle and hormone changes during perimenopause: the key role of ovarian function. Menopause 15:603–612. (PMID: 1857443110.1097/gme.0b013e318174ea4d18574431)
Maki PM, Freeman EW, Greendale GA, Henderson VW, Newhouse PA, Schmidt PJ et al (2010) Summary of the National Institute on Aging-sponsored conference on depressive symptoms and cognitive complaints in the menopausal transition. Menopause 17:815–822. (PMID: 20616668290189310.1097/gme.0b013e3181d763d2)
Frey BN, Lord C, Soares CN (2008) Depression during menopausal transition: a review of treatment strategies and athophysiological correlates. Menopause Int 14:123–128. (PMID: 1871407810.1258/mi.2008.00801918714078)
Mitchell ES, Woods NF (2011) Cognitive symptoms during the menopausal transition and early postmenopause. Climacteric 14:252–261. (PMID: 2152651710.3109/13697137.2010.51684821526517)
Sharwin BB (2016) Estrogen and cognitive functioning in women: lessons we have learned. Behav Neurosci 126:123–127. (PMID: 10.1037/a0025539)
Miller VM, Naftolin F, Asthana S, Black DM, Brinton EA, Budoff MJ et al (2019) The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned? Menopause 26:1071–1084. (PMID: 31453973673862910.1097/GME.0000000000001326)
The North American Menopause Society (NAMS). NAMS 3rd Utian Translational Science Symposium October 2016, Orlando, Florida. A conversation about hormone therapy: is there an appropriate dose, route, and duration of use? Menopause 24:1221–1235.
The NAMS 2017 Hormone Therapy Position Statement Advisory Panel (2017) The 2017 hormone therapy position statement of The North American Menopause Society. Menopause 24:728–753. (PMID: 10.1097/GME.0000000000000921)
Maki PM, Girad LM, Manson JE (2019) Menopausal hormone therapy and cognition. BMJ 364:l877. https://doi.org/10.1136/bmj.l877. (PMID: 10.1136/bmj.l87730842090)
Luine V, Frankfurt M (2012) Interactions between estradiol, BDNF and dendritic spines in promoting memory. Neuroscience 239:34–45. (PMID: 2307962610.1016/j.neuroscience.2012.10.019)
Rikhotso SR, Makuwa GN, Mulaudzi FM (2015) The perceptions of African women regarding natural menopause in Mamelodi, Tshwane district. Curatonis 38(2):1531. https://doi.org/10.4102/curationis.v38i2.1531. (PMID: 10.4102/curationis.v38i2.1531)
Ande AB, Omu OP, Ande OO, Olagbuji NB (2011) Features and perceptions of menopausal women in Benin City, Nigeria. Ann Afr Med 10:300–304. (PMID: 2206425710.4103/1596-3519.87048)
Anstey KJ, Cherbuin N, Herath PM (2013) Development of a new method for assessing global risk of Alzheimer’s disease for use in population health approaches to prevention. Prev Sci 14:411–421. (PMID: 23319292369646210.1007/s11121-012-0313-2)
Gamage MWK, Hewage C, Pathirana KD (2019) Associated factors for cognition of physically independent elderly people living in residential care facilities for the aged in Sri Lanka. BMC Psychiatry 19(1):10. https://doi.org/10.1186/s12888-018-2003-5. (PMID: 10.1186/s12888-018-2003-5306216446325741)
Clare L, Wu Y-T, Teale JC, MacLeod C, Matthews F, Brayne C et al (2017) Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: a cross-sectional study. PLoS Med 14(3):e1002259. https://doi.org/10.1371/journal.pmed.1002259. (PMID: 10.1371/journal.pmed.1002259283238295360216)
فهرسة مساهمة: Keywords: Cognition; Menopausal stage; Menopausal symptoms; Neurocognitive decline; Sub-Saharan Africa
تواريخ الأحداث: Date Created: 20210902 Date Completed: 20211220 Latest Revision: 20211220
رمز التحديث: 20221213
DOI: 10.1007/978-1-0716-1558-4_5
PMID: 34473316
قاعدة البيانات: MEDLINE
الوصف
تدمد:1940-6029
DOI:10.1007/978-1-0716-1558-4_5