دورية أكاديمية
Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation.
| العنوان: | Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation. |
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| المؤلفون: | Do KM; Institute of Natural Medicine, University of Toyama, Toyama, Japan., Shin MK; Institute of Natural Medicine, University of Toyama, Toyama, Japan., Kodama T; Institute of Natural Medicine, University of Toyama, Toyama, Japan., Win NN; Institute of Natural Medicine, University of Toyama, Toyama, Japan., Prema P; Institute of Natural Medicine, University of Toyama, Toyama, Japan.; Department of Chemistry, University of Yangon, Yangon, Myanmar., Nguyen HM; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Hayakawa Y; Institute of Natural Medicine, University of Toyama, Toyama, Japan., Morita H; Institute of Natural Medicine, University of Toyama, Toyama, Japan. |
| المصدر: | Planta medica [Planta Med] 2022 Sep; Vol. 88 (11), pp. 913-920. Date of Electronic Publication: 2021 Sep 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0221 (Electronic) Linking ISSN: 00320943 NLM ISO Abbreviation: Planta Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart ; New York : George Thieme Original Publication: Stuttgart, Hippokrates Verlag. |
| مواضيع طبية MeSH: | Crinum*/metabolism , NF-kappa B*/metabolism, Flavonoids/*chemistry, Animals ; Lipopolysaccharides/pharmacology ; Mice ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Polyphenols ; RAW 264.7 Cells ; Signal Transduction |
| مستخلص: | Three new flavanols, (2 R ,3 S )-7-methoxy-flavan-3-ol (1: ), (2 R ,3 S )-7-hydroxy-flavan-3-ol (2: ), and (2 R ,3 S )-2'-hydroxy-7-methoxy-flavan-3-ol (3: ), together with two known flavans (4: and 5: ), were isolated from the chloroform extract of Crinum asiaticum . Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1: and 3: -5: showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF- κ B pathway mechanisms indicated that 1: and 3: -5: inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF- κ B in RAW264.7 cells, with an effective dose of 10 µM. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.) |
| المشرفين على المادة: | 0 (Flavonoids) 0 (Lipopolysaccharides) 0 (NF-kappa B) 0 (Polyphenols) 31C4KY9ESH (Nitric Oxide) EC 1.14.13.39 (Nitric Oxide Synthase Type II) |
| تواريخ الأحداث: | Date Created: 20210902 Date Completed: 20220907 Latest Revision: 20220908 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1055/a-1585-5877 |
| PMID: | 34474490 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-0221 |
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| DOI: | 10.1055/a-1585-5877 |