دورية أكاديمية
أعرض في EDS

Increased vulnerability to SARS-CoV-2 infection among indigenous people living in the urban area of Manaus.

التفاصيل البيبلوغرافية
العنوان: Increased vulnerability to SARS-CoV-2 infection among indigenous people living in the urban area of Manaus.
المؤلفون: Pontes GS; Laboratório de Imunologia e Virologia, Instituto Nacional de Pesquisas da Amazônia (INPA), Coordenação Sociedade, Ambiente e Saúde, Av. André Araújo, 2936-Petrópolis, Manaus, Amazonas, CEP 69.067-375, Brazil. gemilson.pontes@inpa.gov.br.; Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Imunologia Básica e Aplicada, Manaus, Brazil. gemilson.pontes@inpa.gov.br.; Universidade do Estado do Amazonas, Programa de Pós-Graduação em Ciências Aplicadas à Hematologia, Manaus, Brazil. gemilson.pontes@inpa.gov.br., de Melo Silva J; Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Imunologia Básica e Aplicada, Manaus, Brazil., Pinheiro-Silva R; Universidade do Estado do Amazonas, Programa de Pós-Graduação em Ciências Aplicadas à Hematologia, Manaus, Brazil., Barbosa AN; Laboratório de Imunologia e Virologia, Instituto Nacional de Pesquisas da Amazônia (INPA), Coordenação Sociedade, Ambiente e Saúde, Av. André Araújo, 2936-Petrópolis, Manaus, Amazonas, CEP 69.067-375, Brazil., Santos LC; Universidade Federal do Mato Grosso, Campus do Araguaia, Barra das Garças, Mato Grosso, Brazil., de Pádua Quirino Ramalho A; Departamento de Saúde Coletiva, Universidade Federal do Amazonas (UFAM), Faculdade de Medicina, Manaus, Brazil., de Castro Alves CE; Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Imunologia Básica e Aplicada, Manaus, Brazil., da Silva DF; Instituto Nacional de Pesquisas da Amazônia (INPA), Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Amazônia Legal-PPG-BIONORTE, Manaus, Brazil., de Oliveira LC; Universidade do Estado do Amazonas, Programa de Pós-Graduação em Ciências Aplicadas à Hematologia, Manaus, Brazil., da Costa AG; Universidade Federal do Amazonas (UFAM), Programa de Pós-Graduação em Imunologia Básica e Aplicada, Manaus, Brazil.; Universidade do Estado do Amazonas, Programa de Pós-Graduação em Ciências Aplicadas à Hematologia, Manaus, Brazil.; Escola de Enfermagem de Manaus, Universidade Federal do Amazonas (UFAM), Manaus, Brazil., Bruno AC; Laboratório de Imunologia e Virologia, Instituto Nacional de Pesquisas da Amazônia (INPA), Coordenação Sociedade, Ambiente e Saúde, Av. André Araújo, 2936-Petrópolis, Manaus, Amazonas, CEP 69.067-375, Brazil.
المصدر: Scientific reports [Sci Rep] 2021 Sep 02; Vol. 11 (1), pp. 17534. Date of Electronic Publication: 2021 Sep 02.
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: COVID-19*/blood , COVID-19*/epidemiology , COVID-19*/ethnology , COVID-19 Serological Testing* , Indigenous Peoples* , Pandemics*, SARS-CoV-2/*metabolism, Adolescent ; Adult ; Antibodies, Viral/blood ; Brazil/epidemiology ; Brazil/ethnology ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Male ; Middle Aged
مستخلص: The COVID-19 pandemic threatens indigenous peoples living in suburban areas of large Brazilian cities and has thus far intensified their pre-existing socio-economic inequalities. We evaluated the epidemiological situation of SARS-CoV-2 infection among residents of the biggest urban multiethnic indigenous community of the Amazonas state, Brazil. Blood samples of 280 indigenous people living in the surrounding area of Manaus were tested for the presence of anti-SARS-CoV-2 IgA or IgG antibodies. The risk factors and sociodemographic information were assessed through an epidemiological questionnaire. We found a total positivity rate of 64.64% (95% CI 59.01-70.28) for SARS-CoV-2 infection. IgA and IgG were detected in 55.71% (95% CI 49.89-61.54) and 60.71% (95% CI 54.98-66.45) of the individuals, respectively. Over 80% of positive individuals were positive for both IgA and IgG.No significant difference in positivity rates between genders or age groups was observed. Moreover, the age group ≥ 60 years old showed the highest antibody ratios (IgA mean ratio = 3.080 ± 1.623; IgG mean ratio = 4.221 ± 1.832), while the age groups 13-19 and 20-29 showed the lowest IgA (mean ratio = 2.268 ± 0.919) and IgG ratios (mean ratio = 2.207 ± 1.246), respectively. Individuals leaving the home more frequently were at higher risk of infection (Odds ratio (OD) 2.61; 95% CI 1.00-1.49; p = 0.048). Five or more individuals per household increased fivefold the risk of virus transmission (OR 2.56; 95% CI 1.09-6.01; p = 0.019). The disproportionate dissemination of SARS-CoV-2 infection observed among the study population might be driven by typical cultural behavior and socioeconomic inequalities. Despite the pandemic threat, this population is not being targeted by public policies and appears to be chronically invisible to the Brazilian authorities.
(© 2021. The Author(s).)
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معلومات مُعتمدة: PROCAD AMAZÔNIA 88881.200581/201801 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; FAPEAM-Pró-Estado Program Fundação de Amparo à Pesquisa do Estado do Amazonas
المشرفين على المادة: 0 (Antibodies, Viral)
0 (Immunoglobulin A)
0 (Immunoglobulin G)
تواريخ الأحداث: Date Created: 20210903 Date Completed: 20210913 Latest Revision: 20210913
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8413354
DOI: 10.1038/s41598-021-96843-1
PMID: 34475438
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-96843-1