دورية أكاديمية
أعرض في EDS

Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-κB and HMGB1 signaling pathways in rats.

التفاصيل البيبلوغرافية
العنوان: Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-κB and HMGB1 signaling pathways in rats.
المؤلفون: Lebda MA; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt. lebdam1979@alexu.edu.eg., Elmassry IH; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt., Taha NM; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt., Elfeky MS; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2022 Feb; Vol. 29 (6), pp. 8294-8305. Date of Electronic Publication: 2021 Sep 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH: HMGB1 Protein* , Mastitis*/drug therapy, Animals ; Cattle ; Female ; Humans ; Inflammation/chemically induced ; Lactation ; Lipopolysaccharides ; NF-E2-Related Factor 2 ; NF-kappa B/metabolism ; Oxidative Stress ; Rats ; Rats, Wistar ; Signal Transduction ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
مستخلص: Coliform mastitis is a worldwide serious disease of the mammary gland. Curcumin is a pleiotropic polyphenol obtained from turmeric, but it is hydrophobic and rapidly eliminated from the body. However, nanoformulation of curcumin significantly improves its pharmacological activity by enhancing its hydrophobicity and oral bioavailability. Our study aimed to investigate the possible antioxidant and anti-inflammatory effects of nanocurcumin as a prophylactic against LPS-induced coliform mastitis in rat model, where LPS was extracted from a field strain of Escherichia coli (bovine mastitis isolate). The study was conducted on twenty lactating Wistar female rats divided into four equal groups, and the mastitis model was initiated by injection of LPS through the duct of the mammary gland. The results showed that nanocurcumin significantly attenuated the lipid peroxidation (MDA), oxidized glutathione, the release of pro-inflammatory cytokines (TNF-α and IL-1β), and the gene expression of TLR4, NF-κB p65, and HMGB1. Meanwhile, it improved the reduced glutathione level and Nrf2 activity and preserved the normal alveolar architecture. These findings suggested that nanocurcumin supplementation can be a promising potential protective approach for coliform mastitis.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
References: Aggarwal BB, Gupta SC, Sung B (2013) Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol 169:1672–1692.
AlBasher G, Abdel-Daim MM, Almeer A, Ibrahim KA, Hamza RZ, Bungau S, Aleya L (2020) Synergistic antioxidant effects of resveratrol and curcumin against fipronil-triggered oxidative damage in male albino rats. Environ Sci Pollut Res 27(6):6505–6514.
Al-Kahtani M, Abdel-Daim MM, Sayed AA, El-Kott A, Morsy K (2020) Curcumin phytosome modulates aluminum-induced hepatotoxicity via regulation of antioxidant, Bcl-2, and caspase-3 in rats. Environ Sci Pollut Res 27(17):21977–21985.
Andersson U, Yang H, Harris H (2018) Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert Opin Ther Targets 22:263–277.
Arozal W, Ramadanty WT, Louisa M, Satyana RPU, Hartono G, Fatrin S, Purbadi S, Estuningtyas A, Instiaty I (2019) pharmacokinetic profile of curcumin and nanocurcumin in plasma, ovary, and other tissues. Drug Res (Stuttg) 69:559–564.
Bajic VP, Van Neste C, Obradovic M, Zafirovic S, Radak D, Bajic VB, Essack M, Isenovic ER (2019) Glutathione “redox homeostasis” and its relation to cardiovascular disease. Oxidative Med Cell Longev 2019:5028181–5028181.
Bancroft JD, Gamble M (2008): Theory and practice of histological techniques. Elsevier health sciences.
Barreto F, Jank L, Castilhos T, Rau RB, Tomaszewski CA, Ribeiro C, Hillesheim DR (2019) Chemical residues and mycotoxins in raw milk, Raw milk. Elsevier, pp:273–293.
Bhattarai D, Worku T, Dad R, Rehman ZU, Gong X, Zhang S (2018) Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis. Microb Pathog 120:64–70.
Bisht A, Dickens M, Rutherfurd-Markwick K, Thota R, Mutukumira AN, Singh H (2020) Chlorogenic acid potentiates the anti-inflammatory activity of curcumin in LPS-stimulated THP-1 cells. Nutrients 12:2706.
Boyanapalli SS, Paredes-Gonzalez X, Fuentes F, Zhang C, Guo Y, Pung D, Saw CL, Kong AN (2014) Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin. Chem Res Toxicol 27:2036–2043.
Brouillette E, Malouin F (2005) The pathogenesis and control of Staphylococcus aureus-induced mastitis: study models in the mouse. Microbes Infect 7:560–568.
Carvalho-Sombra TCF, Fernandes DD, Bezerra BMO, Nunes-Pinheiro DCS (2021) Systemic inflammatory biomarkers and somatic cell count in dairy cows with subclinical mastitis. Vet Anim Sci 11:100165.
Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C (2018) Immunomodulators inspired by nature: a review on curcumin and echinacea. Molecules:23.
Chen CY, Kao CL, Liu CM (2018) The cancer prevention, anti-inflammatory and anti-oxidation of bioactive phytochemicals targeting the TLR4 signaling pathway. Int J Mol Sci 19:2729.
Cheng WN, Han SG (2020) Bovine mastitis: risk factors, therapeutic strategies, and alternative treatments - A review. Asian Australas J Anim Sci 33:1699–1713.
Cobirka M, Tancin V, Slama P (2020) Epidemiology and classification of mastitis. Animals 10:2212.
Colagar AH, Pouramir M, Marzony ET, Jorsaraei SGA (2009) Relationship between seminal malondialdehyde levels and sperm quality in fertile and infertile men. Braz Arch Biol Technol 52:1387–1392.
Da W, Zhang J, Zhang R, Zhu J (2019) Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling. Int J Immunopathol Pharmacol 33:2058738419861600.
de Almeida Alvarenga L, de Oliveira LV, Borges NA, de Aguiar AS, Faxén-Irving G, Stenvinkel P, Lindholm B, Mafra D (2018) Curcumin-A promising nutritional strategy for chronic kidney disease patients. J Funct Foods 40:715–721.
Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421–431.
Edwards P, Ewing WJCMM (1972) Identification of Enterobacteriaceae. Burgess Publ:103–104.
Elfeky M, Yoneshiro T, Okamatsu-Ogura Y, Kimura K (2018) Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells. J Biochem 163:143–153.
El-Sayed A, Kamel M (2020) Advanced applications of nanotechnology in veterinary medicine. Environ Sci Pollut Res 27:19073–19086.
Eskiler GG, Özkan AD, Kaleli S, Bilir C (2019) Inhibition of TLR4/TRIF/IRF3 signaling pathway by curcumin in breast cancer cells. J Pharm Pharm Sci 22:281–291.
Fahim KM, Ismael E, Khalefa HS, Farag HS, Hamza DA (2019) Isolation and characterization of E. coli strains causing intramammary infections from dairy animals and wild birds. Int J Vet Sci Med 7:61–70.
Fallahi F, Borran S, Ashrafizadeh M, Zarrabi A, Pourhanifeh MH, Khaksary Mahabady M, Sahebkar A, Mirzaei H (2021) Curcumin and inflammatory bowel diseases: from in vitro studies to clinical trials. Mol Immunol 130:20–30.
Fu Y, Zhou E, Liu Z, Li F, Liang D, Liu B, Song X, Zhao F, Fen X, Li D, Cao Y, Zhang X, Zhang N, Yang Z (2013) Staphylococcus aureus and Escherichia coli elicit different innate immune responses from bovine mammary epithelial cells. Vet Immunol Immunopathol 155:245–252.
Fu Y, Zhou E, Wei Z, Liang D, Wang W, Wang T, Guo M, Zhang N, Yang Z (2014) Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model. FEBS J 281:2543–2557.
Fusco R, Cordaro M, Siracusa R, Peritore AF, D'Amico R, Licata P, Crupi R, Gugliandolo E (2020) Effects of hydroxytyrosol against lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells: a natural therapeutic tool for bovine mastitis. Antioxidants 9:693.
Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, Zhou B, Rodrigues Hoffmann A, Basu R, Guo S, Majeti N (2017) Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. Br J Pharmacol 174:2074–2084.
Glynn DJ, Hutchinson MR, Ingman WV (2014) Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biol Reprod 90:91.
Gomes F, Henriques M (2016) Control of bovine mastitis: old and recent therapeutic approaches. Curr Microbiol 72:377–382.
Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106:207–212.
Gupta SC, Patchva S, Koh W, Aggarwal BB (2012) Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol 39:283–299.
Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 15:195–218.
Hassanzadeh S, Read MI, Bland AR, Majeed M, Jamialahmadi T, Sahebkar A (2020) Curcumin: an inflammasome silencer. Pharmacol Res 104921.
He X, Wei Z, Zhou E, Chen L, Kou J, Wang J, Yang Z (2015) Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in mice. Int Immunopharmacol 28:470–476.
Hosseinia A, Rasaieb D, Aslc SS, Ahmadabadid AN, Ranjbard A (2019) Evaluation of the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure to paraquat in rats. Toxin Rev. https://doi.org/10.1080/15569543.2019.1675707.
Ingman WV, Glynn DJ, Hutchinson MR (2014) Inflammatory mediators in mastitis and lactation insufficiency. Mammary Gland Biol Neoplasia 19:161–167.
Jang J, Hur HG, Sadowsky MJ, Byappanahalli M, Yan T, Ishii S (2017) Environmental Escherichia coli: ecology and public health implications—a review. J Appl Microbiol 123:570–581.
Ji L, Qu L, Wang C, Peng W, Li S, Yang H, Luo H, Yin F, Lu D, Liu X (2020) Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2. Eur J Med Chem 210:112965.
Jiang A, Zhang Y, Zhang X, Wu D, Liu Z, Li S, Liu X, Han Z, Wang C, Wang J (2020) Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-κB and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier. Int Immunopharmacol 78:105972.
Kan X, Liu B, Guo W, Wei L, Lin Y, Guo Y, Gong Q, Li Y, Xu D, Cao Y (2019) Myricetin relieves LPS-induced mastitis by inhibiting inflammatory response and repairing the blood–milk barrier. J Cell Physiol 234:16252–16262.
Khan MZ, Khan A, Xiao J, Ma J, Ma Y, Chen T, Shao D, Cao Z (2020) Overview of research development on the role of NF-κB signaling in mastitis. Animals 10:1625.
Kim DC, Lee W, Bae JS (2011) Vascular anti-inflammatory effects of curcumin on HMGB1-mediated responses in vitro. Inflamm Res 60:1161–1168.
Li X, Zhong CQ, Yin Z, Qi H, Xu F, He Q, Shuai J (2020) Data-driven modeling identifies TIRAP-independent MyD88 activation complex and myddosome assembly strategy in LPS/TLR4 signaling. Int J Mol Sci 21:3061.
Mazgaeen L, Gurung P (2020) Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci 21:379.
Meng F-C, Zhou Y-Q, Ren D, Wang R, Wang C, Lin L-G, Zhang X-Q, Ye W-C, Zhang Q-W (2018) Turmeric: a review of its chemical composition, quality control, bioactivity, and pharmaceutical application. Natural artificial flavoring agents food dyes:299–350.
Mirzaei A, Hedayati M, Re, Ashtiani A, Rahbar M, Rastegar H, Beheshti SJSR, Essays (2011) A simple method for non phenolic extraction of lipopolysaccharide from Salmonella typhimurium and Salmonella enteritidis with high purity and pyrogenicity in rat. 6, 1101-1105.
Moghaddasi F, Housaindokht MR, Darroudi M, Bozorgmehr MR, Sadeghi A (2018) Synthesis of nano curcumin using black pepper oil by O/W nanoemulsion technique and investigation of their biological activities. Food Sci Technol 92:92–100.
Panaro MA, Corrado A, Benameur T, Paolo CF, Cici D, Porro C (2020) The emerging role of curcumin in the modulation of TLR-4 signaling pathway: focus on neuroprotective and anti-rheumatic properties. Int J Mol Sci 21:2299.
Panzarini E, Mariano S, Tacconi S, Carata E, Tata AM, Dini L (2020) Novel therapeutic delivery of nanocurcumin in central nervous system related disorders. Nanomaterials (Basel, Switzerland) 11.
Prantner D, Nallar S, Vogel SN (2020) The role of RAGE in host pathology and crosstalk between RAGE and TLR4 in innate immune signal transduction pathways. FASEB J 34:15659–15674.
Priyadarsini KI (2014) The chemistry of curcumin: from extraction to therapeutic agent. Molecules 19:20091–20112.
Pu HL, Chiang WL, Maiti B, Liao ZX, Ho YC, Shim MS, Chuang EY, Xia Y, Sung HW (2014) Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications. ACS Nano 8:1213–1221.
Quesnell RR, Klaessig S, Watts JL, Schukken YH (2012) Bovine intramammary Escherichia coli challenge infections in late gestation demonstrate a dominant antiinflammatory immunological response. J Dairy Sci 95:117–126.
Quinn PJ (1994) Clinical veterinary microbiology.
Rahimi HR, Nedaeinia R, Sepehri Shamloo A, Nikdoust S, Kazemi Oskuee R (2016) Novel delivery system for natural products: nano-curcumin formulations. Avicenna J Phytomed 6:383–398.
Rai M, Pandit R, Gaikwad S, Yadav A, Gade A (2015) Potential applications of curcumin and curcumin nanoparticles: from traditional therapeutics to modern nanomedicine. Nanotechnol Rev 4:161–172.
Sampath V (2018) Bacterial endotoxin-lipopolysaccharide; structure, function and its role in immunity in vertebrates and invertebrates. Agric Nat Resour 52:115–120.
Schalm OW, Noorlander DO (1957) Experiments and observations leading to development of the California mastitis test. J Am Vet Med Assoc 130:199–204.
Seegers H, Fourichon C, Beaudeau F (2003) Production effects related to mastitis and mastitis economics in dairy cattle herds. Vet Res 34:475–491.
Shi H, Guo Y, Liu Y, Shi B, Guo X, Jin L, Yan S (2016) The in vitro effect of lipopolysaccharide on proliferation, inflammatory factors and antioxidant enzyme activity in bovine mammary epithelial cells. Anim Nutr 2:99–104.
Smulski S, Gehrke M, Libera K, Cieslak A, Huang H, Patra AK, Szumacher-Strabel M (2020) Effects of various mastitis treatments on the reproductive performance of cows. BMC Vet Res 16:99.
Spitzer AJ, Tian Q, Choudhary RK, Zhao F-Q (2020) Bacterial endotoxin induces oxidative stress and reduces milk protein expression and hypoxia in the mouse mammary gland. Oxidative Med Cell Longev 2020:3894309–3894309.
Sun X, Luo S, Jiang C, Tang Y, Cao Z, Jia H, Xu Q, Zhao C, Loor JJ, Xu C (2020) Sodium butyrate reduces bovine mammary epithelial cell inflammatory responses induced by exogenous lipopolysaccharide, by inactivating NF-κB signaling. J Dairy Sci 103:8388–8397.
Suojala L, Kaartinen L, Pyörälä S (2013) Treatment for bovine Escherichia coli mastitis - an evidence-based approach. J Vet Pharmacol Ther 36:521–531.
Suresh S, Sankar P, Telang AG, Kesavan M, Sarkar SN (2018) Nanocurcumin ameliorates Staphylococcus aureus-induced mastitis in mouse by suppressing NF-κB signaling and inflammation. Int Immunopharmacol 65:408–412.
Trivedi MK, Mondal SC, Gangwar M, Jana S (2017) Immunomodulatory potential of nanocurcumin-based formulation. Inflammopharmacology 25:609–619.
Villanueva-Flores F, Castro-Lugo A, Ramirez OT, Palomares LA (2020) Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices. Nanotechnology 31:132002.
Wang C, Nie H, Li K, Zhang YX, Yang F, Li CB, Wang CF, Gong Q (2012) Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice. Eur J Pharmacol 697:152–157.
Wang F-C, Pei J-X, Zhu J, Zhou N-J, Liu D-S, Xiong H-F, Liu X-Q, Lin D-J, Xie YJW Jo GW (2015a) Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro. 21:7764.
Wang FC, Pei JX, Zhu J, Zhou NJ, Liu DS, Xiong HF, Liu XQ, Lin DJ, Xie Y (2015b) Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro. World J Gastroenterol 21:7764–7776.
Weiss J, Barker J (2018): Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity. F1000Res 7.
Yang Y, Han C, Guo L, Guan Q (2018) High expression of the HMGB1–TLR4 axis and its downstream signaling factors in patients with Parkinson’s disease and the relationship of pathological staging. Brain Behavior 8:e00948.
Zambrano LMG, Brandao DA, Rocha FRG, Marsiglio RP, Longo IB, Primo FL, Tedesco AC, Guimaraes-Stabili MR, Rossa Junior C (2018) Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease. Sci Rep 8:6652.
Zangui M, Atkin SL, Majeed M, Sahebkar A (2019) Current evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art. Pharmacol Res 141:343–356.
فهرسة مساهمة: Keywords: LPS; Mastitis; Nanocurcumin; Oxidative stress; TLR4
المشرفين على المادة: 0 (HMGB1 Protein)
0 (Lipopolysaccharides)
0 (NF-E2-Related Factor 2)
0 (NF-kappa B)
0 (TLR4 protein, human)
0 (Tlr4 protein, rat)
0 (Toll-Like Receptor 4)
تواريخ الأحداث: Date Created: 20210905 Date Completed: 20220124 Latest Revision: 20220124
رمز التحديث: 20221213
DOI: 10.1007/s11356-021-16309-9
PMID: 34482462
قاعدة البيانات: MEDLINE
الوصف
تدمد:1614-7499
DOI:10.1007/s11356-021-16309-9