دورية أكاديمية
Cross-sectional associations between adipose tissue depots and areal bone mineral density in the UK Biobank imaging study.
| العنوان: | Cross-sectional associations between adipose tissue depots and areal bone mineral density in the UK Biobank imaging study. |
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| المؤلفون: | Bland VL; Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, 12401 E 17th Ave Rm 368, Aurora, CO, 80045-2589, USA. victoria.bland@cuanschutz.edu., Klimentidis YC; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, 85724, USA., Bea JW; Department of Health Promotion Sciences, University of Arizona, Tucson, AZ, 85724, USA.; The University of Arizona Cancer Center, Tucson, AZ, 85724, USA., Roe DJ; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, 85724, USA.; The University of Arizona Cancer Center, Tucson, AZ, 85724, USA., Funk JL; Department of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA.; Department of Medicine, University of Arizona, Tucson, AZ, 85724, USA., Going SB; Department of Nutritional Sciences, University of Arizona, Tucson, AZ, 85721, USA. |
| المصدر: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2022 Feb; Vol. 33 (2), pp. 391-402. Date of Electronic Publication: 2021 Sep 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: England NLM ID: 9100105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2965 (Electronic) Linking ISSN: 0937941X NLM ISO Abbreviation: Osteoporos Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Springer International, c1990- |
| مواضيع طبية MeSH: | Biological Specimen Banks* , Bone Density*, Absorptiometry, Photon ; Adipose Tissue ; Cross-Sectional Studies ; Female ; Femur Neck/diagnostic imaging ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Male ; United Kingdom/epidemiology |
| مستخلص: | The relationship between obesity and osteoporosis is poorly understood. In this study, we assessed the association between adiposity and bone. The fat-bone relationship was dependent on sex, body mass index classification, and menopausal status. Results highlight the importance of accounting for direct measures of adiposity (beyond BMI) and menopause status. Introduction: Assess the relationship between direct measures of adiposity (total body fat mass, visceral adipose tissue, and abdominal subcutaneous adipose tissue) with the whole body and clinically relevant bone sites of the lumbar spine, and femoral neck areal bone mineral density (aBMD) in men and women. Methods: This cross-sectional analysis was conducted utilizing de-identified data from the UK Biobank on participants (n = 3674) with available dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) data. Sex-stratified multiple linear regression was used to assess the relationship between adiposity measures and aBMD outcomes, controlling for age, race, total body lean mass (DXA), height, BMI class, physical activity, smoking, menopausal status (women), and hormone use (women). Results: In men, significant interactions were observed between measures of adiposity and BMI on aBMD for the whole body and lumbar spine. Interactions indicated a positive relationship between adiposity and aBMD in men classified as normal weight, but an inverse relationship in men with elevated BMI. In women, significant interactions between adiposity measures and menopausal status were observed primarily for the whole body and femoral neck aBMD bone outcomes which indicated a negative relationship between adiposity and aBMD in premenopausal women, but a positive relationship in postmenopausal women. Conclusion: Total body adiposity, abdominal subcutaneous adipose tissue, and visceral adipose tissue were all significantly associated with aBMD in both men and women. The strength and direction of association were dependent on sex, BMI classification, and menopausal status (women). (© 2021. International Osteoporosis Foundation and National Osteoporosis Foundation.) |
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| معلومات مُعتمدة: | MC_PC_17228 United Kingdom MRC_ Medical Research Council; MC_QA137853 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Adiposity; Aging; Bone; DXA; Menopause; Visceral fat |
| تواريخ الأحداث: | Date Created: 20210907 Date Completed: 20220207 Latest Revision: 20220223 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s00198-021-06140-w |
| PMID: | 34490505 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1433-2965 |
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| DOI: | 10.1007/s00198-021-06140-w |