دورية أكاديمية
أعرض في EDS

Combination of D-dimer level and neutrophil to lymphocyte ratio predicts long-term clinical outcomes in acute coronary syndrome after percutaneous coronary intervention.

التفاصيل البيبلوغرافية
العنوان: Combination of D-dimer level and neutrophil to lymphocyte ratio predicts long-term clinical outcomes in acute coronary syndrome after percutaneous coronary intervention.
المؤلفون: Gu LF; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Gu J; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wang SB; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wang H; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wang YX; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Xue Y; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wei TW; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Sun JT; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Lian XQ; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Liu JB; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Jia EZ; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wang LS; Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. drlswang@njmu.edu.cn.
المصدر: Cardiology journal [Cardiol J] 2023; Vol. 30 (4), pp. 576-586. Date of Electronic Publication: 2021 Sep 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Via Medica Country of Publication: Poland NLM ID: 101392712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1898-018X (Electronic) Linking ISSN: 1898018X NLM ISO Abbreviation: Cardiol J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Gdańsk : Via Medica
مواضيع طبية MeSH: Acute Coronary Syndrome*/diagnosis , Acute Coronary Syndrome*/surgery , Percutaneous Coronary Intervention*/adverse effects, Male ; Humans ; Middle Aged ; Neutrophils ; Lymphocytes ; Risk Factors
مستخلص: Background: High D-dimer (DD) is associated with short-term adverse outcomes in patients with acute coronary syndrome (ACS). In ACS patients who underwent percutaneous coronary intervention (PCI), however, the value of DD (or combined with neutrophil to lymphocyte ratio [NLR]) to predict long-term major adverse cardiovascular events (MACEs) has not been fully evaluated.
Methods: Patients diagnosed with ACS and receiving PCI were included. The primary outcome was MACEs. Cox proportional hazards regression and logistic regression were used to illustrate the relationship between clinical risk factors, biomarkers and MACEs. Survival models were developed based on significant factors and evaluated by the Concordance-index (C-index).
Results: The final study cohort was comprised of 650 patients (median age, 64 years; 474 males), including 98 (15%) with MACEs during a median follow-up period of 40 months. According to the cut-off value of DD and NLR, the patients were separated into four groups: high DD or nonhigh DD with high or nonhigh NLR. After adjusting for confounding variables, DD (adjusted hazard ratio [aHR]: 2.39, 95% confidence interval [CI]: 1.52-3.76) and NLR (aHR: 2.71, 95% CI: 1.78-4.11) were independently associated with long-term MACEs. Moreover, patients with both high DD and NLR had a significantly higher risk in MACEs when considering patients with nonhigh DD and NLR as reference (aHR: 6.19, 95% CI: 3.30-11.61). The area under curve increased and reached 0.70 in differentiating long-term MACEs when DD and NLR were combined, and survival models incorporating the two exhibited a stronger predictive power (C-index: 0.75).
Conclusions: D-dimer (or combined with NLR) can be used to predict long-term MACEs in ACS patients undergoing PCI.
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فهرسة مساهمة: Keywords: D-dimer; acute coronary syndrome; long-term outcome; neutrophil to lymphocyte ratio; percutaneous coronary intervention
المشرفين على المادة: 0 (fibrin fragment D)
تواريخ الأحداث: Date Created: 20210907 Date Completed: 20230912 Latest Revision: 20230921
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10508083
DOI: 10.5603/CJ.a2021.0097
PMID: 34490603
قاعدة البيانات: MEDLINE
الوصف
تدمد:1898-018X
DOI:10.5603/CJ.a2021.0097