دورية أكاديمية
Targeting immune checkpoints in gynecologic cancer: updates & perspectives for pathologists.
العنوان: | Targeting immune checkpoints in gynecologic cancer: updates & perspectives for pathologists. |
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المؤلفون: | Mills AM; Department of Pathology, Division of Anatomic Pathology, University of Virginia, Charlottesville, VA, USA. amm7r@virginia.edu., Bullock TN; Department of Pathology, Division of Anatomic Pathology, University of Virginia, Charlottesville, VA, USA., Ring KL; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Virginia, Charlottesville, VA, USA. |
المصدر: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2022 Feb; Vol. 35 (2), pp. 142-151. Date of Electronic Publication: 2021 Sep 07. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 8806605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0285 (Electronic) Linking ISSN: 08933952 NLM ISO Abbreviation: Mod Pathol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Inc. Original Publication: Baltimore, MD : Williams & Wilkins, c1988- |
مواضيع طبية MeSH: | Neoplasms*/genetics , Pathologists*, B7-H1 Antigen/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Immunohistochemistry ; Microsatellite Instability |
مستخلص: | Checkpoint inhibitor-based immunotherapy is increasingly used in the treatment of gynecologic cancers, and most often targets the PD-1/PD-L1 axis. Pathologists should be familiar with the biomarkers required to determine candidacy for these treatments based on existing FDA approvals, including mismatch repair protein immunohistochemistry, microsatellite instability testing, tumor mutation burden testing, and PD-L1 immunohistochemistry. This review summarizes the rationale behind these treatments and their associated biomarkers and delivers guidance on how to utilize and readout these tests. It also introduces additional biomarkers which may provide information regarding immunotherapeutic vulnerability in the future such as neoantigen load; POLE mutation status; and immunohistochemical expression of immunosuppressive checkpoints like LAG-3, TIM-3, TIGIT, and VISTA; immune-activating checkpoints such as CD27, CD40, CD134, and CD137; enzymes such as IDO-1 and adenosine-related compounds; and MHC class I. (© 2021. The Author(s), under exclusive licence to United States & Canadian Academy of Pathology.) |
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المشرفين على المادة: | 0 (B7-H1 Antigen) 0 (Biomarkers, Tumor) |
تواريخ الأحداث: | Date Created: 20210908 Date Completed: 20220404 Latest Revision: 20230210 |
رمز التحديث: | 20231215 |
DOI: | 10.1038/s41379-021-00882-y |
PMID: | 34493822 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1530-0285 |
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DOI: | 10.1038/s41379-021-00882-y |