Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles.
| العنوان: | Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles. |
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| المؤلفون: | Kaplonek P; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Cizmeci D; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Fischinger S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Collier AR; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Suscovich T; Seromyx Systems Inc, Cambridge, MA, USA., Linde C; Seromyx Systems Inc, Cambridge, MA, USA., Broge T; Seromyx Systems Inc, Cambridge, MA, USA., Mann C; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla Institute for Immunology, La Jolla, CA, USA., Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dayal D; Space Exploration Technologies Corp, Hawthorne, CA, USA., Rhee J; Space Exploration Technologies Corp, Hawthorne, CA, USA., de St Aubin M; Brigham Women's Hospital, Boston, MA, USA., Nilles EJ; Brigham Women's Hospital, Boston, MA, USA., Musk ER; Space Exploration Technologies Corp, Hawthorne, CA, USA., Menon AS; Space Exploration Technologies Corp, Hawthorne, CA, USA., Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla Institute for Immunology, La Jolla, CA, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Barouch DH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2021 Aug 31. Date of Electronic Publication: 2021 Aug 31. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | The successful development of several COVID-19 vaccines has substantially reduced morbidity and mortality in regions of the world where the vaccines have been deployed. However, in the wake of the emergence of viral variants, able to evade vaccine induced neutralizing antibodies, real world vaccine efficacy has begun to show differences across the mRNA platforms, suggesting that subtle variation in immune responses induced by the BNT162b2 and mRNA1273 vaccines may provide differential protection. Given our emerging appreciation for the importance of additional antibody functions, beyond neutralization, here we profiled the postboost binding and functional capacity of the humoral response induced by the BNT162b2 and mRNA-1273 in a cohort of hospital staff. Both vaccines induced robust humoral immune responses to WT SARS-CoV-2 and VOCs. However, differences emerged across epitopespecific responses, with higher RBD- and NTD-specific IgA, as well as functional antibodies (ADNP and ADNK) in mRNA-1273 vaccine recipients. Additionally, RBD-specific antibody depletion highlighted the different roles of non-RBD-specific antibody effector function induced across the mRNA vaccines, providing novel insights into potential differences in protective immunity generated across these vaccines in the setting of newly emerging VOCs. |
| التعليقات: | Update in: Sci Transl Med. 2022 Mar 29;:eabm2311. (PMID: 35348368) |
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| معلومات مُعتمدة: | U19 AI135995 United States AI NIAID NIH HHS; K12 HD000849 United States HD NICHD NIH HHS; R01 AI042790 United States AI NIAID NIH HHS; R01 AI146785 United States AI NIAID NIH HHS; 75N93019C00052 United States AI NIAID NIH HHS; U01 CA260476 United States CA NCI NIH HHS; R37 AI080289 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20210908 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| مُعرف محوري في PubMed: | PMC8423223 |
| DOI: | 10.1101/2021.08.31.458247 |
| PMID: | 34494026 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2021.08.31.458247 |
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