دورية أكاديمية
أعرض في EDS

Variations in human body water isotope composition across the United States.

التفاصيل البيبلوغرافية
العنوان: Variations in human body water isotope composition across the United States.
المؤلفون: Valenzuela LO; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Laboratorio de Ecología Evolutiva Humana (LEEH), Unidad de Enseñanza Universitaria Quequén, Facultad de Ciencias Sociales, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Argentina; School of Biological Sciences, University of Utah, USA. Electronic address: lucianoovalenzuela@gmail.com., O'Grady SP; School of Biological Sciences, University of Utah, USA., Ehleringer JR; School of Biological Sciences, University of Utah, USA.
المصدر: Forensic science international [Forensic Sci Int] 2021 Oct; Vol. 327, pp. 110990. Date of Electronic Publication: 2021 Sep 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7902034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6283 (Electronic) Linking ISSN: 03790738 NLM ISO Abbreviation: Forensic Sci Int Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Science Ireland
Original Publication: Lausanne, Elsevier Sequoia.
مواضيع طبية MeSH: Models, Biological*, Body Water/*chemistry , Deuterium/*analysis , Oxygen Isotopes/*analysis, Adult ; Biological Variation, Individual ; Biological Variation, Population ; Body Composition ; Cities ; Drinking Water/chemistry ; Female ; Humans ; Male ; Middle Aged ; United States
مستخلص: Accurate human provenancing using stable isotopes depends directly on solid understandings of the geographic and individual factors affecting isotope variability and incorporation into human tissues. Transfer of isotopic, and therefore spatial, information between environmental water and biological tissues is mediated by the isotopic composition of body water. Thus, there is a need to study body water isotope ratios at a population level and over a large isotopic and geographic range. We evaluated oxygen (δ 18 O bw ) and hydrogen (δ 2 H bw ) isotope values of body water from 72 volunteers in 10 different cities across the US, and over a 5-10-day period. We analyzed covariates (e.g., water intake, physical activity, biometrics, gender) that might explain individual stable isotope ratio variations and tested a predictive model that incorporates the δ-values of drinking water, food, and O 2 as well as individual variables to predict the δ-values of body water. The individual variability in body water isotope values overtime (mean 0.3‰ for δ 18 O bw and 2.3‰ for δ 2 H bw ) was lower than the intra-city variability (mean 0.9‰ for δ 18 O bw and 6.9‰ for δ 2 H bw ). Body water isotope values differed among cities (ANOVA: δ 18 O bw F = 97.2, p < 0.001; δ 2 H bw F = 176.2, p < 0.001). However, significant overlap among some cities with different drinking water was discovered. We detected significant covariation of measured drinking water and human body water isotope values (both isotope systems R 2 ≥ 0.89, p < 0.001) and small but significant effects of the average daily exercise and amount of fluid intake. The differences between measured and model-predicted body water values (mean 0.12 ± 1.2‰ for Δδ 18 O and -1.2 ± 8.2‰ for Δδ 2 H) were statistically indistinguishable from zero (Δδ 18 O t = -0.751, p = 0.45; Δδ 2 H t = 1.133, p = 0.26). Here we show that community level variation exists in the δ 18 O bw and δ 2 H bw values and the primary drivers are the regional differences in drinking water isotopes. Consistency of the body water isotope composition over the study period suggests that tissues would incorporate a stable isotope signal over time. The amount of drinking water and physical activity influence body water values, while the variation in the isotopic values of food may contribute to regional level variability, but that still remains to be assessed further. The human body water model provides accurate estimates for measured values, capturing and reproducing the main features of the body water isotope variation across space.
Competing Interests: Declaration of Interest The authors declare no conflicts of interests.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Biogeochemistry; Body Water; Predictive model; Region of origin; Stable isotopes
المشرفين على المادة: 0 (Drinking Water)
0 (Oxygen Isotopes)
AR09D82C7G (Deuterium)
تواريخ الأحداث: Date Created: 20210909 Date Completed: 20211027 Latest Revision: 20211027
رمز التحديث: 20221213
DOI: 10.1016/j.forsciint.2021.110990
PMID: 34500129
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6283
DOI:10.1016/j.forsciint.2021.110990